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MEDTECH Cabozantinib plus nivolumab and ipilimumab (C-N-I) is a new combination therapy for patients with advanced renal cell carcinoma (RCC). In a phase 3 clinical trial, C-N-I was shown to be superior to sunitinib in terms of progression-free survival (PFS) and overall survival (OS).
The trial enrolled 823 patients with advanced RCC who had not received prior systemic therapy. Patients were randomly assigned to receive either C-N-I (n=412) or sunitinib (n=411). The primary endpoint of the trial was PFS, and the secondary endpoint was OS.
At a median follow-up of 24 months, patients who received C-N-I had a significantly longer PFS than patients who received sunitinib. The median OS for patients who received C-N-I was not reached, while the median OS for patients who received sunitinib was 22.8 months.
