Articles related to Internal Medicine

On September 20, 2022, Alzheon Inc. announced promising results from its phase 2 trial of oral ALZ-801 (valiltramiprosate) in patients with early AD. The drug decreased p-tau181 levels, reduced brain atrophy, and improved cognitive skills in the trial.

A 70-year-old woman with a skin lesion on her right temple is referred for assessment. She claims that the site originally came to light about a year ago and has grown in size ever since. An erythematous, fibrotic plaque with a depressed center is discovered during examination. What is the most likely cause of the lesion?

A young Black man has been troubled by recurring papules and crusting pustules in the hairline at the back of his neck. What is the disorder and how would you treat it?

A 29-year-old woman bought a genetic test that includes BRCA analysis. She comes to you with the results and asks for guidance. The results are negative for BRCA1 and BRCA2, but she has a positive family history for breast cancer. What do you advise?

The first set of guidelines for critical illness-related corticosteroid insufficiency (CIRCI) was published in 2008. In this review of critical illness-related corticosteroid insufficiency, the author reviews the current thinking regarding this relatively newly defined complex and the changing recommendations for management.

A quartet of current clinical trials involving first-in-class molecules and CRISPR gene editing show great promise. STELLAR investigates a fusion protein in PAH, CodeBreak 200 studies a first-in-class of KRAS inhibitor, EMERGENT-2 focuses on a new treatment for schizophrenia, and NCT04601051 studies a gene editing drug for one form of amyloidosis.