Articles related to Obstetrics & Gynecology

This review and commentary from the ESMO Virtual Congress 2020 features a look at the following trials: ASCENT (sacituzumab govitecan-hziy), IMpassion130 (atezolizumab + nab-paclitaxel), IMpassion131 (first-line paclitaxel +/– atezolizumab), IPATunity130 (ipatasertib + paclitaxel), SEASTAR (rucaparib + sacituzumab govitecan), FLIPPER (fulvestrant/palbociclib), SOLAR-1 (alpelisib + fulvestrant), and FURVA (vandetanib + fulvestrant).

The American Society of Clinical Oncology (ASCO) published a guideline update about the selection of optimal adjuvant chemotherapy regimens and targeted therapy for early breast cancer, namely trastuzumab emtansine. In a second recommendation, the ASCO guideline addressed the use of biosimilar forms of trastuzumab—five of which have been approved by the FDA.

The British Medical Journal’s executive editor, Kamran Abbasi, pens a commentary about DANMASK-19, the first trial of mask use during COVID-19 and its controversial “negative” results. Abbasi claims that disagreement among experts, especially about interpretation of a study, is a common occurrence and “the usual business of science,” but the influence of social media has created a major challenge for science.

In the new study, published December 1, 2020, in the open-access journal eLife, researchers from UC San Francisco showed the drug, ISRIB, produced rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.

From MedPage Today comes this story about Cliff Willmeng, a registered nurse who was fired from United Hospital in St. Paul, MN, in May 2020. Willmeng believes the hospital board is investigating his conduct due to his standing up for his own safety and that of other nurses when he pressed for hospital scrubs over using and reusing his own, fearing he may bring the virus home.

According to a study published in The Journal of Physiology in 2020, even passive stretching can provide health benefits. Instead of focusing on peak performance, pushing yourself to the limit, or “feeling the burn,” here are four other exercises that have been scientifically proven to produce serious benefits without a serious commitment.