A study published in Blood Advances finds that higher levels of NETosis in myeloproliferative neoplasms (MPNs) are not linked to thrombotic events. The study determined that while NETosis may play a role in facilitating thrombosis, it is not a sole causative determinant in MPN-associated thrombophilia.
A phase 2 clinical trial involving 486 patients examined whether fulvestrant or letrozole is more effective in treating advanced breast cancer. The results, published in JAMA Oncology, confirmed that letrozole is the preferred treatment in patients with advanced forms of breast cancer. Although fulvestrant demonstrated significant antitumor activity, it did not significantly impact the overall […]
Publication: JAMA Internal MedicineDesign: Retrospective cohort study of more than 83,000 propensity-scored matched pairs over a 12-year period.Results: Diabetes progression was significantly greater among diabetes patients using statins vs. those not using statins.
The exact ways in which COVID-19 is impacting children, particularly those under age 12, is still being examined. Reported at the IDWeek conference, Arkansas health officials presented data demonstrating the severe impact that the fast-moving Delta variant of COVID-19 can have on children. Key findings: From January 2021, the Delta variant led to 42% more […]
In practice, “standard” duration of antibiotic therapy is often based on archaic studies. Newer evidence shows that shorter durations are often a better choice and that antibiotic resistance is more likely to develop with longer durations of therapy. Here are the recommendations applied to four commonly treated infections.
Bone marrow failure in children and young adults is often suspected to be inherited; however, in many cases, diagnosis remains uncertain. A new study involving 179 patients (from 173 families) found that implementing precision medicine at diagnosis can improve patient management, along with the use of family counseling. This study published in Blood expands the […]
Curious about the long-term impacts of COVID-19? A new study that involved 2,433 hospitalized patients found that the most common symptoms after one year were fatigue, sweating, chest tightness, anxiety, and myalgia. The study, conducted in Wuhan, China, one of the global epicenters of the pandemic, also found that patients with severe disease had more […]
Evidence is mounting that much of the concern about waning immunity to COVID-19 is overstated and that vaccines provide high levels of protection against the respiratory disease and its variants over the long-term. Immunologically, plasmablast and B-cell response after mRNA vaccination is long-lived and memory B cells increase over at least six months. And in […]
Our understanding of lipid pathology is shifting from what might be called the “LDL hypothesis” to the “atherogenic lipoprotein hypothesis.” LDL is just a surrogate of the actual process of lipoprotein interaction with the arterial wall. This shift in understanding is driving a host of budding therapies with novel approaches to targeting key atherogenesis players […]
When preparing to treat a patient for osteoporosis, it might be wise to compare leading guidelines because guidelines from two key organizations often don’t agree. The ACP and the National Osteoporosis Foundation (NOF) have come up with guidelines that differ in terms of what therapies, how long to treat, how long between scans, and more. […]