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The New England Journal of MedicineEarly Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension

In 60 medical centers, 1,500 patients were randomized to either a restrictive or liberal fluid strategy. The 90-day mortality rate was 14% in the fluid-restrictive group and 14.9% in the liberal group, equating to statistical equivalence between the two approaches.

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