Articles related to COLORECTAL CANCER (CRC)

Data on patients with mismatch repair deficiency (MMRD) CRC, the majority of whom could not undergo surgery due to various health conditions unrelated to cancer, were presented at the 2023 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI). Instead of radiation therapy or chemotherapy, the patients received immunotherapy with checkpoint inhibitors. It should be noted that the patients were treated outside of clinical trials. The overall response rate in this patient group was 74%, with 57% of those who responded experiencing complete tumor regression. Some of the patients have been in complete remission for a year or more after their diagnoses. The data indicate that immunotherapy is an effective treatment for patients who are unable to undergo surgery for a variety of reasons, including advanced age or a variety of health issues.

Adenoma detection rate (ADR) is inversely correlated with postcolonoscopy (PC) CRC incidence risk in a fecal immunochemical test (FIT)-based screening program, necessitating adequate colonoscopy quality monitoring in this situation. The likelihood of PCCRC may be considerably decreased by raising endoscopists’ ADR.

The researchers tested whether a ctDNA-guided strategy could lower the need for adjuvant chemotherapy without increasing the risk of recurrence. Recurrence-free survival at 2 years was the main efficacy end objective. Adjuvant chemotherapy usage was a significant secondary end goal.

Both as oral monotherapy and in combination with cetuximab, adagrasib exhibited antitumor activity in patients who had received prior treatment and had metastatic colorectal cancer with mutant KRAS G12C. In the group receiving combination therapy, the median response time was greater than 6 months. Reversible negative outcomes were frequent in both groups.

The master cell growth regulator mTORC1 is known to be hyperactive in colon cancer. This study shows that in mice, a low protein diet blocked mTORC1’s nutrient signaling pathway, stopping the cancer from growing and leading to increased cancer cell death.

In a study originally published in British Journal of Sports Medicine, a sample of nearly 100,000 adults showed that after making adjustments for other activity, weight training was associated with a 9% decline in CVD mortality. A separate study published in Medicine & Science in Sports & Exercise showed a lower risk of colorectal cancer in adults who lifted weights.