Peer-influenced content. Sources you trust. No registration required. This is HCN.
The New England Journal of Medicine
Cabozantinib plus nivolumab and ipilimumab (C-N-I) is a new combination therapy for patients with advanced renal cell carcinoma (RCC). In a phase 3 clinical trial, C-N-I was shown to be superior to sunitinib in terms of progression-free survival (PFS) and overall survival (OS). The trial enrolled 823 patients with advanced RCC who had not received prior systemic therapy. Patients were randomly assigned to receive either C-N-I (n=412) or sunitinib (n=411). The primary endpoint of the trial was PFS, and the secondary endpoint was OS. At a median follow-up of 24 months, patients who received C-N-I had a significantly longer PFS than patients who received sunitinib. The median OS for patients who received C-N-I was not reached, while the median OS for patients who received sunitinib was 22.8 months.
Oncology, Medical May 16th 2023
This study compared the efficacy and safety of four different treatment regimens for patients with chronic lymphocytic leukemia (CLL): chemoimmunotherapy, venetoclax-rituximab, venetoclax-obinutuzumab, and venetoclax-obinutuzumab-ibrutinib. The results showed that the venetoclax-obinutuzumab-ibrutinib regimen was the most effective, with significantly higher rates of undetectable minimal residual disease (MRD) and progression-free survival (PFS) at 15 months and 3 years, respectively, compared to the other regimens. The venetoclax-obinutuzumab regimen was also effective, with significantly higher rates of undetectable MRD at 15 months compared to chemoimmunotherapy. However, there was no significant difference in PFS at 3 years between the venetoclax-obinutuzumab and chemoimmunotherapy regimens. The venetoclax-rituximab regimen was the least effective, with no significant difference in undetectable MRD or PFS at 15 months or 3 years compared to chemoimmunotherapy. The most common adverse events were infections, which were more common with chemoimmunotherapy and venetoclax-obinutuzumab-ibrutinib than with the other regimens.
Hematology May 16th 2023
OBR Oncology
The 2023 AACR meeting has seen a large number of clinical abstracts presented, demonstrating that science from the lab is moving to the clinic. Examples include an RNA vaccine from Moderna in combination with pembrolizumab in a neoadjuvant setting in patients with melanoma, and the AEGEAN trial, which looks at perioperative therapy in patients with lung cancer. The conference is also seeing a focus on more diverse speakers, including junior investigators. The field of mRNA cancer vaccines is evolving, with personalised vaccines being used to activate the immune system in combination with checkpoint inhibitors, resulting in positive results in some cancers. The conference is an opportunity to learn about new science, make new connections and collaborations, and gain a better understanding of how to push the field forward.
Oncology, Medical May 1st 2023
Fox Chase Cancer Center
Bispecific antibodies are molecules that are designed to engage or bind to two distinct targets, bringing two distinct cells together. The majority of those that have received regulatory approval are T-cell-engaging bispecific antibodies. Blinatumomab (Blincyto) for ALL, teclistamab (Tecvayli) for multiple myeloma, and mosunetuzumab-axgb (Lunsumio) for follicular lymphoma are some examples of FDA-approved treatments. Glofitamab, another bispecific antibody, is currently under FDA Priority Review for the treatment of R/R DLBCL. Another type of immunotherapy is chimeric antigen receptor (CAR) T-cell therapy, but bispecific antibodies provide the same spectrum of side effects with much less toxicity and are showing promise in solid tumors as well.
Hematology April 10th 2023
Penn Medicine
In this video, Dr. Robert Vonderheide, the Director of the Abramson Cancer Center at Penn Medicine, discusses cancer interception, an approach to cancer treatment that involves identifying and treating pre-cancerous cells before they develop into tumors. Dr. Vonderheide explains that cancer interception involves using genomic sequencing to identify cells that are at high risk of developing into cancer and then using drugs or other treatments to kill these cells before they become cancerous. He notes that cancer interception has the potential to be a highly effective form of cancer treatment, but that it requires a collaborative approach between researchers, clinicians, and patients. Dr. Vonderheide also discusses the role of immunotherapy in cancer interception and the challenges associated with developing effective interception strategies for different types of cancer.
Oncology, Medical March 27th 2023
JAMA Network
Immunotherapy combinations with activity in patients with microsatellite stable (MSS) metastatic colorectal cancer are needed, and the recommended phase 2 dose of RIN had a manageable safety profile and an overall response rate of 27.6%, a median progression-free survival of 4 months, and a median overall survival of 20 months in this nonrandomized clinical trial of 39 patients with metastatic colorectal cancer. Patients with no liver metastases received responses (overall response rate, 36.4%; median overall survival not reached).
Oncology, Medical March 20th 2023