American Society of HematologyA Landscape of Germ Line Mutations in a Cohort of Inherited Bone Marrow Failure (IBMF) Patients

Bone marrow failure in children and young adults is often suspected to be inherited; however, in many cases, diagnosis remains uncertain. A new study involving 179 patients (from 173 families) found that implementing precision medicine at diagnosis can improve patient management, along with the use of family counseling. This study published in Blood expands the […]

American Society of HematologyPosttransplantation MRD Monitoring in Patients w. AML by Next-Generation Sequencing Using DTA and Non-DTA Mutations

In this article from Blood Advances highlighted by helpful visual abstracts, two key points are discussed. First, patient-specific next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring using non-DTA mutations after allogeneic hematopoietic cell transplantation (alloHCT) is independently prognostic for relapse and survival. Second, the kinetics rather than a single time point should be further evaluated […]

American Society of HematologyClinical and Molecular Predictors of Response and Survival Following Venetoclax Therapy in R/R AML

In this “Clinical Trials & Observations” report/visual abstract from the pages of Blood Advances (ASH), the authors focus on two key points: 1) In patients with R/R AML, venetoclax combination therapy resulted in responses in 31% of patients and a median OS of 6.1 months, and 2) NPM1 mutations predicted higher response rates; adverse cytogenetics […]