American Medical AssociationAssessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-Risk Breast Cancer

Publication: JAMA Oncology Design: An analysis of data from the I-SPY2 randomized clinical trial that included 938 women with breast cancer.Results: In this randomized clinical trial, the prognostic significance of RCB was consistent regardless of cancer subtype and treatment.

American Society of Clinical OncologyOn the Absence of Sound

How could complete silence possibly be considered music (John Cage’s 4’33”), or a blank canvas a masterpiece of art (Robert Rauschenberg’s White Painting)? This oncology medical student explains how after truly listening to a dying patient’s wishes, the student’s silence provided the canvas for the patient’s thoughts, becoming an advocate for his needs: “Silence is […]

Everyday HealthClinical Challenge: Hematologic Malignancy and COVID-19

The inaugural report of the ASH Research Collaborative (RC) COVID-19 Registry for Hematology, published in Blood Advances, is based on an analysis of the first 250 patients with both hematologic malignancy and COVID-19 registered from 74 countries. The analysis showed that the mortality risk (28% overall and increased to 42% among hospitalized patients with COVID-19) […]

Wyanoke GroupAAP Updates Guidelines on Long-Term Care for Cancer Survivors

This is the third edition of the guidelines – the last coming in 2014 – providing a resource and guidance specifically for primary care practitioners about how to plan care for childhood cancer survivors. “A care plan just really encourages coordination, especially if a child has a very complicated post-cancer treatment history with a lot […]

American Academy of PediatricsCDC: Delta Variant Causing Increase in Pediatric COVID-19 Cases, Not Severity

The two new studies in the Morbidity and Mortality Report compared data from July and August 2021 – when delta was dominant to the earlier period in the pandemic – and found that about 1.4 of every 100,000 children/adolescents were hospitalized for COVID-19, nearly 5x the weekly rate in late June and close to the […]

American Medical AssociationSpontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Publication: JAMAMethod: Electronic health record (EHR) data from 8 health systems over seven 4-week surveillance periods to identify and assign gestational ages for spontaneous abortions and ongoing pregnancies; analyzed and compared odds of receiving a COVID-19 vaccine in the 28 days prior to spontaneous abortion and ongoing pregnancies.Results: Of 105,446 unique pregnancies, 13,160 spontaneous abortions […]

Haymarket MediaTreatment Approaches Differ by Age Group in Extremity Soft Tissue Sarcoma

Reference Source: JAMA Network OpenDesign: Retrospective study of 8,953 patients from the National Cancer Database; compared the use of definitive treatment between 2004 and 2014 of 1,280 young adults (YAs, aged 18-39 years); 3,937 patients aged 40-64 years; and 3,756 patients age 65+.Results: Amputation – 8.1% (YAs), 5.5% (40-64), 5.3% (65+). Chemotherapy – 39.4% (YAs), […]

Everyday HealthMMWR COVID Data — Strong Benefit of Vaccinating Previously Infected

Is the debate over? The Morbidity and Mortality Weekly Report (MMWR) discusses this case-control study, which showed that people are twice as likely to get infected again if they are unvaccinated. The debate over vaccinations has been bitter so far, but the results present comforting news for those vaccinated but worried about the fast-spreading Delta […]