Articles related to PEDIATRIC ONCOLOGY

A phase 3 randomized trial of 449 children with intracranial ependymoma found no significant event-free or overall survival benefit from adding maintenance chemotherapy after radiation, while molecular markers — particularly 1q gain and 6q loss — identified a high-risk posterior fossa subgroup with substantially worse outcomes.

Retrospective analysis of pediatric cancer survivors identified low overall CHIP prevalence, with antimetabolite therapy and methotrexate exposure emerging as the strongest treatment-associated signals.

Hereditary TTP, an ultra-rare ADAMTS13 deficiency affecting roughly one in a million, is now managed with weekly recombinant ADAMTS13 infusions in a pediatric outpatient setting.

When confronted with poor outcomes, hope remains essential, but defining it becomes more challenging. Nurses may struggle to understand how to incorporate hope into care, regardless of patient outcomes.

Silent inactivation (where neutralizing antibodies reduce enzymatic activity without clinical symptoms) can go undetected without therapeutic drug monitoring, leading to subtherapeutic asparagine depletion and increased relapse risk.

Cancer incidence rates increased for several cancer types in many of the countries studied; however, other than colorectal cancer, these increases occurred in both younger and older adults.