American Society of HematologyMore Insight into the Role of NETosis in Thrombotic Events in Myeloproliferative Neoplasms

A study published in Blood Advances finds that higher levels of NETosis in myeloproliferative neoplasms (MPNs) are not linked to thrombotic events. The study determined that while NETosis may play a role in facilitating thrombosis, it is not a sole causative determinant in MPN-associated thrombophilia.

American Medical AssociationIntervention Reduces “Death Rattle” in End-of-Life Care

Publication: JAMADesign: Multicenter, randomized, double-blind, placebo-controlled trial performed in six hospices in the Netherlands of 162 patients with a life expectancy of three or more days. Administration of subcutaneous scopolamine butylbromide, 20 mg four times a day (n = 79) or placebo (n=78) in the 157 patients included in the primary analysis.Results: A death rattle occurred in […]

Wyanoke GroupThe Toll for Delta Variant is Severe in Children

The exact ways in which COVID-19 is impacting children, particularly those under age 12, is still being examined. Reported at the IDWeek conference, Arkansas health officials presented data demonstrating the severe impact that the fast-moving Delta variant of COVID-19 can have on children. Key findings: From January 2021, the Delta variant led to 42% more […]

American Society of HematologyA Landscape of Germ Line Mutations in a Cohort of Inherited Bone Marrow Failure (IBMF) Patients

Bone marrow failure in children and young adults is often suspected to be inherited; however, in many cases, diagnosis remains uncertain. A new study involving 179 patients (from 173 families) found that implementing precision medicine at diagnosis can improve patient management, along with the use of family counseling. This study published in Blood expands the […]

Millennium Medical PublishingManagement of Well-Differentiated Neuroendocrine Tumors

Surgery still offers the best chance of cure for patients with neuroendocrine tumors (NETs). However, for locally advanced or metastatic well-differentiated tumors, medical therapy including theranostics, targeted therapies, and chemotherapy can all play a role. Clinical Advances in Hematology & Oncology reviews the diagnosis and management of these tumors.

American Medical AssociationSymptoms and Health Outcomes Among Survivors of COVID-19 Infection After One Year

Curious about the long-term impacts of COVID-19? A new study that involved 2,433 hospitalized patients found that the most common symptoms after one year were fatigue, sweating, chest tightness, anxiety, and myalgia. The study, conducted in Wuhan, China, one of the global epicenters of the pandemic, also found that patients with severe disease had more […]

The BMJCOVID-19 Vaccination: Evidence of Waning Immunity is Overstated

Evidence is mounting that much of the concern about waning immunity to COVID-19 is overstated and that vaccines provide high levels of protection against the respiratory disease and its variants over the long-term. Immunologically, plasmablast and B-cell response after mRNA vaccination is long-lived and memory B cells increase over at least six months. And in […]

American Society of HematologyHow I Treat Pediatric Acute Myeloid Leukemia

In this series from Blood that tackles four cases studies, the outcomes of AML pediatric patients compared to children with ALL is explored, focusing on the emerging new treatments venetoclax (Venclexta; AbbVie/Genentech), CD33- and CD123-directed CAR T-cell therapy, CD123-directed antibody therapy, and menin inhibitors.