Articles related to TRANSPLANTATION
Gene Therapy in Patients with the Crigler–Najjar Syndrome
This phase 1–2 study of gene therapy in Crigler–Najjar syndrome patients offers promising insights into a novel treatment approach. Explore the detailed findings to understand how this therapy could revolutionize the management of this rare and severe condition.
Gastroenterology August 22nd 2023
70 Deaths Linked to the Organ Transplant and Procurement Network, Prompting Reform
The Organ Transplant and Procurement Network (OTPN) is set to undergo modernization and improvement after being criticized for lack of transparency, long waits, mishandling of organs, and the number of people who die on the waitlist each year. The Health Resources and Services Administration (HRSA) has launched the OTPN modernization project, which will focus on accountability. The current system is outdated and has been responsible for 70 deaths between 2010 and 2020, according to a 2022 senate report. The HRSA plans to take steps, such as creating a new dashboard, to provide transparency and better serve patients and their families. Additional modernization will focus on overhauling the operations of the OTPN system to ensure higher compliance and a greater focus on patient safety. Organ transplants and the OTPN disproportionately affect the Black community in the US. About 30% of the ONTP waitlist is Black Americans, and about 90% are waiting for kidney transplants. The HRSA’s plan hopes to address the inequality by improving accountability, transparency, and systems of organ retrieval and matching. The changes will benefit patients, and physicians might be able to see more of their patients receive the life-saving transplants they need.
Cardiology April 24th 2023
Allogeneic Hematopoietic Cell Transplantation vs. Standard Consolidation Chemotherapy in Patients with Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial
The findings of this randomized clinical trial support the notion that, despite improved DFS, patients 60 years or younger with intermediate-risk AML, as defined by Medical Research Council cytogenetic criteria, do not benefit from allo-HCT during first CR in terms of OS. Early identification of a suitable donor allows for the timely rescue of patients who have relapsed following conventional consolidation chemotherapy. Future research that uses longitudinal monitoring of residual disease dynamics will aid in personalizing the optimal time point for allo-HCT in the majority of patients.
Hematology March 27th 2023
MKSAP Quiz: 1-week History of Burning Pain, Rash
This 62-year-old man had a lung transplant 3 years previously for IPF and is on tacrolimus, mycophenolate, and prednisone. Which therapy is most appropriate for their zoster outbreak? IV acyclovir Oral famciclovir Oral valacyclovir Herpes zoster vaccine
Allergy & Immunology January 19th 2023
A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules
Are the findings a result of bacterial endocarditis? Resurgent sarcoidosis? An opportunistic fungal pulmonary invasion? Review the workup and cast your vote on what you think the diagnosis is.
Allergy & Immunology December 7th 2022
Landmark Pig Heart Recipient Had Xenograft Failure, Porcine Virus
The story of David Bennett, age 57, who had severe cardiac failure and was denied a traditional human heart transplant from several programs when he ultimately agreed to the experimental xenotransplant. On day 34, the patient showed no signs of rejection of the porcine heart, but by day 49, sudden diastolic thickening and antibody-mediated failure of the xenograft prevented any lifesaving measures, and he died on day 60.
Cardiology July 13th 2022