Another win for Merck and Keytruda, as the FDA granted accelerated approval to pembrolizumab in combination with chemotherapy for the treatment of patients with locally recurrent unresectable or metastatic TNBC whose tumors express PD-L1 based on PFS. The FDA also approved a companion diagnostic, PD-L1 IHC 22C3 pharmDx.
Are traditional cytotoxic chemotherapies becoming a thing of the past? This study in the Journal of Clinical Oncology shows a move toward targeted agents, as a combination of obinutuzumab, ibrutinib, and venetoclax induced deep remissions in patients with treatment-naive or relapsed/refractory chronic lymphocytic leukemia.
In this article from the Journal of Clinical Oncology, the authors suggest the need for caution and well-conducted trials to systematically address the question of total neoadjuvant therapy (TNT) in rectal cancer, which can lead to overtreatment and unnecessary toxicity without a proven benefit. Despite some of its theoretical advantages, declaring TNT a new standard […]
Medical practices incorporate digital apps to improve online scheduling, send appointment reminders, and provide telemedicine options. And physicians now have entire medical libraries at their fingertips to confirm a diagnosis, check drug interactions, and collaborate with other HCPs. Here are some of the most popular medical apps for doctors, nurses, and medical students.
In the past decade, several promising immunotherapies have been developed, changing the treatment landscape for children with relapsed ALL. These advances in treatment offer real promise for less toxic and more effective therapy for children. In this article from Blood, the authors present several cases highlighting contemporary treatment decision-making.
ASH Clinical News speaks with Maureen Achebe, MD, MPH, Clinical Director of the Non-Malignant Hematology Clinic at Brigham and Women’s Hospital in Boston, and other experts about the safety and efficacy of IV iron products, how they are perceived in the community, and barriers to their use in the clinic.
In this Celebrity Diagnosis opinion piece from MedPage Today, the author discusses the legendary guitarist’s original throat cancer diagnosis, its possible causes – including Eddie’s own theory — and how it spread to other parts of his head and neck. The article also examines the risks, symptoms, and treatment options of head and neck cancers.
In this article/podcast from the pages of KevinMD.com, the physician authors describe their distress upon hearing and reading the recent disparaging comments about osteopathic medicine, which attacked Navy Commander Dr. Sean Conley, DO, the Physician of the President: “When someone challenges the validity of a legitimate medical degree, the entire house of medicine is under […]
Anthony Fauci, MD, director of the National Institutes of Allergy and Infectious Diseases (NIAID), joined Lungcast, a respiratory health podcast series from HCPLive and the American Lung Association (ALA), to discuss the CDC’s varying take on SARS-CoV-2 transmission and testing parameters. Fauci also shared suggestions for college campus to mitigate community-based spread while classes continue.
In this editorial from The New England Journal of Medicine, the authors criticize the country’s leadership on its response to the COVID-19 pandemic, presenting several pieces of evidence to reinforce their claims. From politicizing the Food and Drug Administration to undercutting trust in science and government, the leaders of our nation are “causing damage that […]