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GUIDELINES/RECOMMENDATIONS Anaphylaxis to the mRNA COVID-19 vaccines is currently estimated to occur in 2.5 to 11.1 cases per million doses, largely in individuals with a history of allergy. In this JAMA “Research Letter”, the authors investigated acute allergic reaction incidence with more than 60,000 mRNA COVID-19 vaccine administrations at Mass General Brigham (MGB).
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