Articles related to Urology

In this 3rd case in a short series, the author describes integration of next-generation PSMA imaging with conventional imaging, including CT and bone scans. The author reviews the rationale for triple therapy with darolutamide, ADT, and docetaxel, and reviews the key phase III studies on triple therapy in prostate cancer: the ENZAMET, PEACE-1 and ARASENS trials.

This large surgically staged cohort of high-risk patients with preoperative PSMA PET evaluated the accuracy of Ga-68-PSMA-PET/CT for primary nodal staging. The findings suggest that total lesion uptake values could provide valuable presurgical staging information and might aid in predicting risk of lymph node metastasis in patients with prostate cancer.

Anal intercourse is becoming more common among heterosexual couples. In the US, 30-44% of men and women report experience of anal sex. There are a host ofnegative health implications, especially for women, that should be communicatedespecially so patients can make truly informed decisions.

In this case, the second in a three-part series, a man was diagnosed with prostate cancer based on a prostate-specific antigen (PSA) level of 6.5 ng/mL. The initial diagnosis was stage 3 disease (T3, N0, M0), with a Gleason score of 3+4=7. The rationale for the treatment decisions is explained, along with the trials (ARAMIS, SPARTAN, PROSPER) that influenced the decisions.

Some physicians believe that Gleason 6 should be reclassified as something other than cancer, which could be a valid argument because Gleason 6 isn’t going to cause any harm and therefore can be safely observed. This commentary provides arguments as to why that reclassification idea is a flawed concept.

The study was comprised of 17,913 men with a median age of 64 years with pT2-4N1M0 prostate cancer (PC) consecutively treated between 1995 and 2017, with postradical prostatectomy (RP) and pelvic lymph node (LN) assessment. The patients were then followed for possible treatment with adjuvant radiation therapy (aRT) or early salvage radiation therapy (sRT). It was determined that men with pN1 PC and 4 or more as compared with 1-3 positive pelvic LNs appear to benefit the most from the use of aRT.