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Articles related to Obstetrics & Gynecology

Pain Medicine News

New AANA Obstetric Guidelines Prioritize Addressing Gaps in Health Equity

Anesthesiology May 24th 2023

Oncology Nurse Advisor

Permissive Cardiotoxicity Strategy Improves Completion of Trastuzumab Cycles in HER2-Positive Breast Cancer

Permissive cardiotoxicity strategy could enhance trastuzumab treatment outcomes in HER2-positive breast cancer patients, despite requiring more research into its long-term safety. A study conducted at McMaster University and published in The Oncologist explored the feasibility of a permissive cardiotoxicity strategy in patients with HER2-positive breast cancer undergoing trastuzumab treatment. Although trastuzumab significantly improves outcomes in these patients, up to 4% of them may experience cardiac dose-limiting toxicity (cDLT), resulting in therapy discontinuation, which can negatively impact patient outcomes. The researchers employed a retrospective cohort study of 51 patients who had been referred to the cardio-oncology service between January 2016 and May 2021 for left ventricular dysfunction after trastuzumab administration. Notably, a permissive cardiotoxicity strategy was applied, which allows the continuation of trastuzumab therapy while closely monitoring mild to moderate cardiotoxicity. The primary outcomes for this study were left ventricular (LV) function and completion of an entire course of trastuzumab. Astonishingly, 92% of patients (47 out of 51) were able to complete their full course of HER2-targeted therapy without experiencing cDLT. However, 6% developed cDLT during trastuzumab treatment, and even after discontinuation, they were more likely to experience persistent cardiotoxicity. Interestingly, despite most patients regaining their LV function post-treatment, 14% persisted […]

Obstetrics & Gynecology May 22nd 2023

The New England Journal of Medicine

Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Emergency Medicine May 18th 2023

Northwestern Medicine

Feinberg Again Ranks Among Top Medical Schools in the Nation

Anesthesiology May 17th 2023


Updates to Mammography Regulations: What Your Patients Need to Know

Obstetrics & Gynecology May 16th 2023

The New England Journal of Medicine

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal

Neurology May 9th 2023

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