Articles related to Gastroenterology

The American Cancer Society updated its colorectal cancer screening guidelines to include two new multitarget stool tests and a blood-based option, while maintaining colonoscopy as the gold standard and the age-45 screening initiation recommendation for average-risk adults.

In a 794-patient randomized trial, early-stage type 2 diabetes patients uncontrolled on metformin who received tirzepatide achieved nearly twice the HbA1c reduction of those on intensified conventional care at 2 years, and 60% reached normoglycemia (HbA1c <5.7%), compared to 24% in the ICC arm.

An Oregon gastroenterology group was hit with a $25M wrongful death verdict after a 43-year-old patient with obesity, obstructive sleep apnea, and hypertension died during a routine outpatient colonoscopy, with liability centered on the decision to perform the procedure in a lower-acuity setting despite a risk profile that plaintiffs argued warranted a hospital environment.

Two Lilly-sponsored placebo-controlled trials found that adults who transitioned from high-dose injectable GLP-1 therapy to either oral tirzepatide (Foundayo) or a reduced 5 mg tirzepatide maintenance dose preserved most of their prior weight loss over one year, compared to substantial regain in placebo arms.

A narrative review of UCLA spice research found associations between common culinary spices — cinnamon, turmeric, red pepper, and spice blends — and glucose regulation, gut microbiome composition, and cognitive markers, though most findings stem from small trials and in vitro work using supratherapeutic doses.

A 21-element enhanced recovery protocol implemented across 18 US hospitals reduced inpatient opioid use by 56% in children undergoing GI surgery, with patients receiving 13 or more protocol elements averaging one fewer hospital day and half the complication risk.