LGBTQ+ physicians may face additional burnout-related stressors associated with workplace discrimination, microaggressions, and exclusion, highlighting the potential role of inclusive organizational cultures and supportive professional resources in physician well-being.

Biobehavioral markers previously linked to antidepressant response identified patients with major depressive disorder who were more likely to respond to sertraline or bupropion, although biomarker-guided treatment assignment did not significantly improve outcomes in a prospective validation trial.

Women with bulimia nervosa demonstrated smaller total cortical surface area and reduced nucleus accumbens volume compared with healthy controls in a large international neuroimaging study, with more frequent binge-eating episodes associated with additional structural differences across brain regions involved in reward, cognitive control, and interoception.

First-trimester benzodiazepine exposure was not associated with a meaningful increase in major congenital malformations in a large US cohort study, although findings related to coexposure with other psychoactive medications remained inconsistent and require further investigation.

The FDA has approved once-monthly subcutaneous olanzapine for adults with schizophrenia, supported by placebo-controlled trial data showing symptom improvement and sustained efficacy through 48 weeks, while eliminating several logistical requirements associated with treatment initiation.

Cannabis use at psychiatric admission was associated with a higher risk of early rehospitalization among young adults hospitalized for bipolar or psychotic disorders, although the association weakened over time and was no longer statistically significant by six months.