A hospitalist review of updated AHA resuscitation guidance highlights changes involving cardioversion energy, vascular access, POCUS, postarrest oxygen and temperature targets, medication use, and ethical decision-making during resuscitation.

Frailty in a 68-patient ATTR-CM cohort was independently associated with more advanced amyloidosis stage and greater functional impairment, while age and interventricular septal thickness were not independently associated with frailty.

Intensive blood-pressure lowering reduced major cardiovascular events similarly in adults with and without chronic kidney disease, without increasing kidney failure risk, although sustained declines in estimated glomerular filtration rate occurred more frequently.

Continued anabolic-androgenic steroid use was associated with persistent left ventricular hypertrophy and dysfunction, while discontinuation accompanied improved cardiac structure and systolic function. Small, nonrandomized subgroups limit conclusions about reversibility and treatment effects.

Higher moderate-to-vigorous physical activity was associated with lower incident atrial fibrillation risk in a UK Biobank cohort, with a stronger association among participants with atrial cardiomyopathy. The observational design does not establish causality.

Losartan increased brown-fat metabolic activity in cell and mouse experiments, while a large imaging analysis linked brown fat and ARB exposure with favorable metabolic patterns. Whether the drug can produce similar metabolic effects clinically remains unproven.