A widely shared r/medicine thread drew candid, self-identified physician commentary on which specialties absorb the most interprofessional scrutiny, with emergency medicine and primary care drawing the heaviest fire.

A Cureus case report describes complete fecaloma resolution after two 1 L Classic Coca-Cola enemas in an 82-year-old woman with dementia whose impaction failed conservative management.

Boehringer Ingelheim’s SYNCHRONIZE-1 phase 3 trial reported 16.6% average body weight reduction with survodutide, a dual GLP-1/glucagon receptor agonist, over 76 weeks in adults without type 2 diabetes.

Rodent and non-human primate studies showed glucagon and GIP agonism alone produced weight loss comparable to GLP-1-containing triple agonists in a Bluewater Biosciences-funded program.

Three recent studies examined associations between vitamin D status and outcomes across type 2 diabetes risk, Alzheimer’s biomarkers, and inflammatory bowel disease in exploratory cohorts.

A SARS-CoV-2 variant designated BA.3.2, or “Cicada,” has been added to the WHO variants under monitoring list, with wastewater detection across at least 25 US states and 132 locations.