The reported death of Senator Lindsey Graham following a suspected aortic dissection has renewed attention on a condition that can mimic other cardiovascular emergencies. Existing guidelines emphasize surveillance, risk-factor management, and timely recognition in high-risk patients.

Objective sleep measurements from nearly 61,000 adults linked greater sleep regularity with lower all-cause, cancer, and cardiometabolic mortality risk. Sleep regularity outperformed sleep duration in mortality prediction models.

A European Heart Journal debate revisits whether surgical aortic valve replacement should remain the preferred approach for patients with aortic stenosis and life expectancy beyond five years. Long-term durability and late procedural outcomes continue to shape the discussion.

Among more than 117,000 women followed in two Nurses’ Health Study cohorts, greater resistance-training participation was associated with lower rates of major cardiovascular disease. Risk reductions were most pronounced when strength training was paired with aerobic exercise.

A new ACC scientific statement summarizes current evidence for antiplatelet therapy across primary prevention, ACS, PCI, CAD, and PAD management. The document emphasizes individualized assessment of ischemic and bleeding risks.

The FDA approved enlicitide, the first oral PCSK9 inhibitor, after phase 3 studies demonstrated substantial LDL-C reductions in patients requiring additional lipid lowering. Cardiovascular outcomes data remain pending.