“By comparing current standard-of-care treatments with a potential novel therapy in refractory mCRC, this review underscores existing gaps and highlights future research priorities while awaiting randomized data.” – Elisabetta Bengala, MD, Regina Elena National Cancer Institute, Rome, Italy

Disease recurrence in HR+/HER2– early BC (EBC) can occur over decades; however, the hazard of recurrence is highest during the first 2 years of adjuvant endocrine therapy, a period associated with endocrine resistance and early metastatic progression.

The primary end point was the area under the curve (AUC) of the daily worst bone pain score (assessed using the “worst pain” question from the Brief Pain Inventory, a 0 to 10 numerical rating scale [NRS]) for 5 consecutive days in the first chemotherapy cycle.

The study introduced an ML-based, tunable risk stratification strategy tailored for AML patients treated with venetoclax plus azacitidine. By addressing real-world data limitations and incorporating diverse diagnostic features, the approach enables more accurate and adaptable prognostic modeling than traditional systems, supporting personalized treatment decisions and broader clinical applicability.

To help patients and clinicians in strategizing about care decisions at the individual level, ASH convened a multidisciplinary panel — which included experts and patient representatives — to form standardized guidelines for newly diagnosed AML in older patients.

Because the patient was complaining of both chest discomfort and dyspnea–which can be caused by vomiting and dehydration–the clinician must consider a potential coronary etiology, even in a 38-year-old.