A 16-year-old girl presented with acute aphasia and right-sided weakness consistent with a large-vessel stroke syndrome. Neuroimaging confirmed left middle cerebral artery occlusion, but the underlying etiology was not immediately apparent.

Reevaluation of major hormone therapy studies has prompted renewed discussion about menopause treatment in breast cancer survivors. Emerging interpretation of older trial data suggests treatment risks may vary by patient characteristics and hormone formulation rather than applying uniformly across all populations.

Older adults with diabetes and frailty frequently experience overtreatment despite individualized glycemic goals that prioritize safety over intensive control. A narrative review highlights deprescribing strategies, relaxed glycemic targets, and medication adjustments intended to reduce hypoglycemia, falls, and treatment burden.

Adults with type 2 diabetes initiating GLP-1 receptor agonists experienced higher rates of nonscarring alopecia than matched users of SGLT-2 or DPP-4 inhibitors. The association persisted across multiple analyses, though absolute risk remained low.

Online claims linking GLP-1 receptor agonists to increased penis size continue attracting patient attention. Available evidence suggests perceived changes may reflect weight loss and erectile function changes rather than anatomic growth.

The federal government has sharply reduced staffing and grant funding at AHRQ, the agency responsible for much of the nation’s healthcare quality and patient safety research. Supporters argue the cuts could affect future evidence generation, though the administration maintains it is restructuring agency priorities.