The FDA approved olezarsen (Tryngolza), an apoC-III antisense inhibitor, as an adjunct to diet for reducing triglycerides and acute pancreatitis risk in adults with severe hypertriglyceridemia, based on phase 3 data showing an 85% reduction in pancreatitis events compared with placebo.

Dr. Nidhi Madan discusses building a rural structural heart program at Bassett Medical Center, the health equity gaps keeping high-burden patients from reaching heart team evaluation, and why cardiac CT fluency has become a foundational competency for the modern structural interventionalist.

A 4-week randomized trial in 20 obese men with hypercholesterolemia found that intermittent hypoxic training combined with caloric restriction produced greater reductions in LDL-C, total cholesterol, and triglycerides compared with normoxic training under identical dietary conditions.

A Bayesian network meta-analysis of 31 randomized trials found aerobic, combined, and high-intensity interval training each associated with reductions in 24-hour ambulatory systolic blood pressure compared with control conditions, with no modality demonstrating clear superiority and all comparisons rated very low to low confidence.

Among nearly 450,000 Scottish adults with hypertension, participants using a digital home blood pressure telemonitoring system showed lower rates of cardiovascular events, hospitalizations, and death compared with those receiving standard care over a median observation period spanning 2019 to 2022.

A 553-respondent UK survey of cardiology resident doctors found that nearly one-third reported witnessing physician assistants performing procedures outside defined scope of practice, with earlier-stage trainees reporting the most negative impact on training opportunities.