Based on the researchers’ series, patients who develop VS after an inciting event or related to an underlying comorbidity may have a better prognosis than those in whom it develops spontaneously.

The reseachers acknowledge that the Delphi approach favors compounds already studied and may exclude agents identifiable only through high-throughput screening.

The NSGC CPC strongly recommends that all individuals with unexplained epilepsy be offered genetic testing, regardless of age.

The 2024 McDonald criteria continue to emphasize the importance of considering differential diagnoses, including reevaluating the diagnosis periodically over the disease course, even after a diagnosis of MS has been made.

“A 65% reduction in the risk of death and a statistically significant extension in median survival of over 14 months represent a clinically meaningful benefit of notable magnitude in ALS.” — Alon Ben-Noon, CEO, Neurosense Therapeutics

The new chemical entity is an atypical antipsychotic and the active metabolite of iloperidone (Fanapt). Its ability to cross the blood-brain barrier likely contributes to iloperidone’s clinical effects.