Analysis of genetic testing data from nearly 180,000 individuals with autism suggests that Phelan-McDermid syndrome may affect approximately 1 in 7,300 people. The findings indicate the condition may be substantially more common than previously estimated and highlight ongoing diagnostic gaps.

Analysis of 900 fungal isolates from pediatric invasive fungal infections found low overall resistance rates to azoles and echinocandins across most species. Isavuconazole demonstrated activity comparable to established triazoles against many clinically important molds and yeasts.

The FDA expanded approval of the CRISPR-based gene therapy Casgevy to include patients as young as 2 years with sickle cell disease or transfusion-dependent beta thalassemia. The decision was supported by pediatric phase 3 data demonstrating sustained reductions in disease burden.

Accumulating evidence suggests that initiating effective therapy earlier in Crohn’s disease may reduce bowel damage progression, hospitalizations, and surgery. Long-term follow-up from recent studies has strengthened interest in a therapeutic window during which disease modification may be achievable.

Genetic analyses of nearly 80,000 infants identified variants associated with toddler activity levels and other early behavioral traits. Several of these genetic signals overlapped with those previously linked to ADHD and autism, although the findings do not establish causality.

An Arizona toddler was pronounced dead following resuscitation efforts and later discovered alive in a hospital morgue hours afterward. The unusual case has prompted investigation into death determination, communication, and post-resuscitation safety processes.