A network meta-analysis of 716 randomized trials and 159,362 participants found ARB-based regimens had the lowest rates of treatment discontinuation due to adverse effects, with the ARB-CCB combination ranking as the best-tolerated dual-drug option among antihypertensive regimens examined.

A meta-analysis of 232,655 out-of-hospital cardiac arrest cases found no statistically significant difference in favorable neurologic outcomes or survival to hospital discharge between bystander standard CPR with ventilation and chest compression-only CPR.

A Medicare cohort study found a median delay of 494 days between incident heart failure diagnosis and ATTR-CM diagnosis, with female sex, aortic stenosis, COPD, coronary artery disease, diabetes, and hypertension associated with longer diagnostic delays.

An interventional cardiologist at UCLA Health describes how combined IVUS and near-infrared spectroscopy imaging identified culprit lesions in angiographically ambiguous NSTEMI cases and informed stent landing zone decisions in complex PCI.

Four major societies jointly published the first multidisciplinary guideline for cardiovascular-kidney-metabolic syndrome, introducing a standardized staging system and unified treatment framework across cardiology, nephrology, endocrinology, and primary care.

Each additional hour of daily digital screen exposure was associated with 21% higher odds of myopia in a 335,524-participant meta-analysis, with the steepest odds increase observed between 1 and 4 hours of daily exposure, though substantial heterogeneity and cross-sectional study designs precluded causal conclusions.