In an observational target trial emulation of patients with atrial fibrillation and mitral stenosis, DOACs were associated with higher 1-year stroke risk than warfarin. Bleeding and all-cause mortality risks did not differ between groups.

A case report describes successful kidney transplantation in a highly sensitized patient whose probability of finding a compatible donor had been considered effectively zero. Treatment with teclistamab substantially reduced anti-HLA antibodies, enabling transplantation after prolonged wait-list status.

A mathematical modeling study estimated that somatic DNA mutations alone could limit median human life span to roughly 146 to 194 years. The findings add to ongoing research suggesting that aging reflects multiple interacting biological processes rather than a single mechanism.

A gastroenterologist reflects on changing attitudes toward physician work culture, describing how younger physicians increasingly prioritize personal well-being alongside professional responsibilities. The commentary frames the shift as a response to longstanding expectations around endurance, productivity, and burnout.

Two long-term proton pump inhibitor users presented with severe macrocytic anemia, markedly elevated LDH, and low haptoglobin suggestive of hemolysis. Further evaluation identified combined vitamin B12 and folate deficiency, highlighting a diagnostic mimic of true hemolytic anemia.

A growing debate in airway management centers on whether clinicians should favor the term “complex airway” over “difficult airway.” An expert commentary argues that both concepts describe different dimensions of risk and should remain part of a shared airway-management vocabulary.