Melatonin supplements are widely thought of as a safe and ‘natural’ option to support better sleep, so it was striking to see such consistent and significant increases in serious health outcomes, even after balancing for many other risk factors.

Findings from both trials showed treatment with elinzanetant led to a statistically significant reduction (≥2 hot flashes over 24 hours) in the frequency of moderate to severe VMS compared with placebo at both 4 and 12 weeks across OASIS 1 and 2 studies.

The ovary, it turns out, is wired—literally connected to the body’s sympathetic nervous system—and this neural network appears to play a key role in how and when eggs mature.

This case highlights how important it is to consider neurological variables when shortness of breath cannot be explained by cardiac or respiratory problems in acute situations.

Given that human-targeted drugs are often taken continuously throughout life, not for short periods, which is the case for antibiotics, the physiological effects can be even more profound.

The FDA’s Class II designation indicates that exposure or usage of ‘a violative product may cause temporary or medically reversible adverse health consequences or where the probability of serious adverse health consequences is remote.’