A pediatric adverse-event database analysis found disproportionate reporting of psychotic symptoms with several antibiotics relative to minocycline. Presented at a conference, the findings identify a safety signal but do not establish causation or incidence.

A scenario-based article examines an alprazolam request from a patient anticipating election-night anxiety, alcohol use, and possible zolpidem exposure. It emphasizes individualized assessment and communication, without reporting outcomes or establishing a universal prescribing rule.

A randomized trial found greater symptom improvement with single-dose intranasal mebufotenin than with a low-dose control in treatment-resistant depression. Most higher-dose recipients met discharge criteria within two hours; longer-term outcomes remain uncertain.

An expert panel reviewing two network meta-analyses found favorable efficacy rankings for adjunctive lumateperone in major depression, alongside higher discontinuation risks. The indirect comparisons do not establish superiority over other agents.

In mice, psilocybin accelerated dendritic spine formation and maturation, with different remodeling patterns in stressed and healthy brains. Genetic experiments separated these structural effects from head-twitch behavior, a proxy rather than a direct measure of hallucinations.

Registry-recorded antibiotic prescriptions beginning in later childhood were associated with IBS at age 24 in a Swedish cohort. Higher prescription counts accompanied higher odds, but the findings do not establish causality or when symptoms began.