Articles related to Geriatrics
Beers Criteria for Potentially Inappropriate Medication Use in Older Adults (Feb. 2022 Update)
Published in its entirety in the Journal of the American Geriatrics Society and available here from Guideline Central, the AGS Beers Criteria® also includes a host of resources— from mobile apps to a pocket reference card. The five lists included describe particular medications with evidence suggesting they should be avoided, used in caution, or dosed differently.
Family Medicine/General Practice March 8th 2022
Elderly Man Presents With Bradycardia and Chronic Kidney Dysfunction
An interesting case study in BRASH (bradycardia, renal failure, atrioventricular blockade, shock, and hyperkalemia) syndrome highlights Rare Disease Day, which took place on 2/28/22. After reviewing the patient’s history and symptoms, would you agree on the diagnosis?
Cardiology March 1st 2022
Risks of Mental Health Outcomes in People with COVID-19: Cohort Study
The British Medical Journal reports that people who survive COVID-19 are at increased risk of an array of mental health disorders, including anxiety, depression, and opioid use disorder, cognitive decline, sleep disorders, and more. The authors recommend close monitoring of patients following infection and up-prioritizing managing their mental health disorders.
Allergy & Immunology March 1st 2022
A Reasonable Approach to Orthostatic Hypotension
A study published in the Cleveland Clinic Journal of Medicine puts forward a new and systematic approach to diagnosing and managing orthostatic hypotension. The article notes that current approaches to evaluating and managing the disease are based on limited data, but that patients would benefit from more consistent diagnosis and treatment methods.
Cardiology January 25th 2022
Comparative Fracture Risk During Osteoporosis Drug Holidays After Long-Term Risedronate vs. Alendronate Therapy
A new study has found that people with osteoporosis may experience less protection and be subject to more bone fractures when treated with the drug risedronate. Patients who were treated with risedronate during a drug holiday experienced more hip and other fractures than patients given other medications. Drug holidays are recommended after three to five years on therapy for most people taking bisphosphonates for osteoporosis. Risedronate, with its shorter half-life compared with alendronate, is associated with a somewhat higher risk of hip fracture during a drug holiday.
Endocrinology, Diabetes, Metabolism January 19th 2022
Sustained uMRD Demonstrated in Elderly CLL Patients Receiving Ibrutinib Plus Venetoclax
The GLOW study is a phase 3 clinical trial evaluating the efficacy and safety of ibrutinib plus venetoclax (I+V) in elderly or unfit CLL patients. Patients receiving I+V are compared to patients receiving chlorambucil plus obinutuzumab (C+O). Previously this study reported reduced risk of disease progression with I+V vs C+O. This update, presented at ASH 2021, looked at undetectable minimal residual disease (uMRD) – a surrogate for PFS. uMRD was significantly higher in both peripheral blood and bone marrow in the I+V group.
Geriatrics January 12th 2022