Articles related to AGING

A manufacturer-funded randomized trial involving 61 participants reported improved vascular function markers and lower systolic blood pressure with a multi-ingredient supplement over six months. Cardiovascular event reduction and long-term safety were not established.

Analysis of 189 colorectal tumors linked younger age to differences in stromal composition and gene activity. Additional datasets supported the stromal finding, but the study did not establish that these patterns cause aggressive disease.

Proteomic analysis of normal ovaries from 28 postmenopausal women identified age-associated differences in inflammation and tissue remodeling. The findings describe molecular activity, not restored fertility, and do not establish cancer risk or benefits from ovarian removal.

Frailty in a 68-patient ATTR-CM cohort was independently associated with more advanced amyloidosis stage and greater functional impairment, while age and interventricular septal thickness were not independently associated with frailty.

Analysis of postmenopausal ovarian tissue from 28 women found that ovaries continue to undergo molecular remodeling decades after menopause, with age-related increases in inflammatory and tissue-remodeling pathways that overlap with biologic processes observed in ovarian cancer.

Hypertension was associated with osteoarthritis in a Korean population analysis and accelerated cartilage deterioration through vasopressin signaling in mouse models, identifying a potential disease pathway whose therapeutic relevance in humans remains unproven.