Articles related to Infectious Diseases

The FDA approved cefepime-zidebactam (Zaynich) for complicated UTI and pyelonephritis caused by susceptible gram-negative organisms. Approval followed phase 3 trial data showing higher rates of symptom and microbiologic resolution compared with meropenem in hospitalized adults.

The FDA has approved the first generic version of baloxavir marboxil, a single-dose influenza antiviral noninferior to oseltamivir, ahead of the 2026-2027 flu season.

The FDA expanded approval of Capvaxive, a pneumococcal 21-valent conjugate vaccine, to children and adolescents aged 2 to 17 years with at least one chronic medical condition increasing pneumococcal disease risk, based on STRIDE-13 trial data showing noninferiority to PPSV23 across 12 shared serotypes and statistically significantly higher OPA GMTs for 9 serotypes unique to Capvaxive.

A 509,926-patient Medicare cohort found that recombinant herpes zoster vaccination was associated with a 5.8 percentage point reduction in 4-year dementia risk among older adults following skilled-nursing facility admission, adding to a growing body of observational evidence linking RZV to cognitive protection.

The 2026 Surviving Sepsis Campaign pediatric guidelines issued 61 recommendations covering infection recognition, hemodynamics, ventilation, and long-term follow-up for children with sepsis or septic shock.

A Senate investigative report alleged that federal health officials received early signals of myocarditis and pericarditis following mRNA COVID-19 vaccination in adolescents and young adults months before public advisories were issued, citing internal agency communications and subpoenaed HHS documents.