Articles related to PHARMACOTHERAPY

A patient with PNH and persistent anemia during ravulizumab therapy experienced improved hemoglobin after danicopan was added, while an extended infusion delay highlighted treatment-continuity challenges without establishing protection from interrupted C5 inhibition.

New consensus guidance favors once-daily oral iron and simplified IV administration, including fewer test doses, premedications, and infusion visits. Several recommendations depart from established protocols and require formulation-specific clinical judgment.

A multisociety consensus paper outlines hospital-level strategies to improve sepsis outcomes, emphasizing diagnostic stewardship, antimicrobial optimization, surveillance, infection prevention, and multidisciplinary infrastructure while prioritizing interventions judged most feasible and impactful for broad implementation.

An editorial in Obesity highlights emerging evidence that GLP-1 receptor agonists may provide benefits beyond weight loss and glycemic control, while emphasizing unresolved questions regarding muscle preservation, nutritional status, and potential effects on substance use disorders.

Atorvastatin reduced major cardiovascular events among adults aged 70 years and older without known cardiovascular disease, diabetes, or dementia, but the benefit did not translate into a statistically significant improvement in disability-free survival over nearly six years of follow-up.

Two phase 3 trials found upadacitinib increased scalp, eyebrow, and eyelash regrowth in adolescents and adults with severe alopecia areata. Longer-term safety, durability, and regulatory review remain important considerations.