Articles related to METABOLIC HEALTH

Among 46 children initially at healthy weight, greater ultraprocessed food intake was associated with stronger dorsal striatal responses to appetizing food cues, which were also associated with increased adiposity measures 1 year later.

A 67-year-old man with obesity and obesity-related liver disease underwent endoscopic sleeve gastroplasty after previous weight-loss approaches, including GLP-1 therapy, provided insufficient durability, ultimately reporting a weight loss exceeding 80 lb.

In a 48-participant randomized study, a prescribed high-fiber dietary intervention produced greater short-term improvements in BMI and HbA1c than metformin alone in adults with newly diagnosed type 2 diabetes and overweight or obesity.

Losartan increased brown-fat metabolic activity in cell and mouse experiments, while a large imaging analysis linked brown fat and ARB exposure with favorable metabolic patterns. Whether the drug can produce similar metabolic effects clinically remains unproven.

Across three cohorts, molecular patterns in human milk were associated with maternal nutritional status, mammary biological signatures, and infant growth. Seven candidate biomarkers emerged, but their clinical utility and the proposed vitamin B5 mechanism remain unproven.

An editorial in Obesity highlights emerging evidence that GLP-1 receptor agonists may provide benefits beyond weight loss and glycemic control, while emphasizing unresolved questions regarding muscle preservation, nutritional status, and potential effects on substance use disorders.