Articles related to PRECLINICAL RESEARCH

Loss of the membrane-regulating protein NSF in dopamine D2 receptor-expressing neurons was associated with hyperactivity, impulsive behavior, and reduced striatal dopamine signaling in mice. The findings offer mechanistic insight into ADHD biology, although clinical relevance remains unproven.

A multiplexed cytokine and tumor-antigen mRNA immunotherapy produced durable tumor responses in mouse models of pancreatic ductal adenocarcinoma, with approximately half of treated animals remaining disease-free for up to one year, although clinical relevance remains unproven.

Maternal anti-HPA-1a antibodies inhibited β3 integrin activation in laboratory models, with stronger functional inhibition in severe FNAIT cases. The findings suggest a mechanism beyond platelet clearance, but clinical validation remains necessary.

Researchers identified distinct neuronal populations within the heart’s intrinsic nervous system that regulate cardiac rhythm and stress responses in mice. The findings provide mechanistic insight into cardiac neurobiology, though human relevance remains uncertain.

A novel small molecule, CN045, promoted oligodendrocyte maturation and modest remyelination in preclinical models of multiple sclerosis. The findings support an emerging strategy aimed at repairing damaged myelin, though clinical applicability remains unproven.

University of Oklahoma researchers identified a photoreceptor lysosomal recycling pathway regulated by PIKfyve. Mouse-model disruption produced photoreceptor degeneration and RPE changes resembling macular degeneration biology.