Articles related to PRECLINICAL RESEARCH

Synthetic DNA molecules known as polypurine reverse Hoogsteen hairpins reduced PCSK9 expression and lowered LDL cholesterol by approximately 50% in preclinical models, representing an early-stage gene-targeted approach distinct from existing monoclonal antibody and RNA interference strategies.

Brain glucose levels regulated oligodendrocyte progenitor cell proliferation and maturation in mouse and cell models, with ketone bodies restoring myelin production when glucose use was disabled.

Rodent and non-human primate studies showed glucagon and GIP agonism alone produced weight loss comparable to GLP-1-containing triple agonists in a Bluewater Biosciences-funded program.

Brain endothelial cells exposed to a single sugar-free drink’s worth of erythritol shifted toward a pro-thrombotic state. Here’s how to talk about it without overstating the signal.

Melittin, a peptide in bee venom, disrupted cancer cell membranes in preclinical animal and laboratory models, with triple-negative breast cancer cells showing particular susceptibility.

Preclinical findings point to a potential role for extracellular vesicles in cartilage repair, offering insight into future directions for osteoarthritis research.