Articles related to OSTEOARTHRITIS (OA)
Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial
This in-depth research opens up potential avenues for the use of ADMSCs in managing K-L grade 3 knee osteoarthritis, particularly in terms of pain and functional improvements, signifying a promising frontier in osteoarthritis treatment.
Surgery, Orthopedic July 12th 2023
Resiniferatoxin Gets Breakthrough Therapy Status for Knee Osteoarthritis Pain
Unveiling a new path in osteoarthritis pain management, the FDA’s Breakthrough Therapy designation for resiniferatoxin marks a promising development. The FDA has granted Breakthrough Therapy designation to resiniferatoxin for treating osteoarthritis knee pain. Extracted from a cactus-like plant, resiniferatoxin, a potent TRPV1 agonist, boasts similarities to capsaicin. Notably, its potency sets it apart. Resiniferatoxin is administered through intra-articular injection, promoting pain relief by temporarily disabling TRPV1-expressing nociceptors. This unique mechanism targets one of the most profound symptoms of osteoarthritis: pain. Its potential benefits are eagerly awaited by millions of patients struggling with this relentless disease. Stepping up to the challenge, Grünenthal, the company behind resiniferatoxin, is launching a global Phase 3 program. They aim to enroll more than 1,800 patients with knee osteoarthritis who haven’t found sufficient relief from existing non-surgical treatments. With a focus on improved pain and physical function scores according to the WOMAC osteoarthritis index, the program’s efficacy endpoints are set for up to 52 weeks. Turning the tide in osteoarthritis treatment, the Breakthrough Therapy Designation offers an expedited path for this non-opioid therapy option. As Grünenthal’s Chief Scientific Officer, Jan Adams, optimistically noted, it is hoped that this designation will speed up resiniferatoxin’s availability to patients.
Clinical Pharmacology May 31st 2023
Why Do I Have Tight Jaw Muscles? Causes and Relief
Jaw tightness and pain, also known as temporomandibular joint (TMJ) tightness, can be caused by various factors. Stress or anxiety can lead to muscle tension in the jaw, resulting in tightness and discomfort. TMJ disorders, teeth grinding (bruxism), tetanus infection, rheumatoid arthritis (RA), and osteoarthritis (OA) are other potential causes. To relieve a tight jaw, patients can try jaw joint stretches, opt for a soft food diet, and use mouthguards to prevent teeth grinding. Treatment options may include shortwave diathermy, hot and cold compresses, medication, or even acupuncture. It’s important for patients to consult a doctor or dentist if symptoms worsen or interfere with daily activities. By addressing the underlying cause and providing appropriate remedies, dental professionals can help patients find relief from jaw tightness and pain.
Dentistry May 15th 2023
High- vs. Low-Dose Exercise Therapy for Knee Osteoarthritis
A 12-month controlled trial randomized 189 individuals to spend 70–90 minutes performing 11 exercises or 20–30 minutes performing 5 exercises for 3 months. Outcomes were measured biweekly for the intervention period and again at 6 and 12 months. The two approaches were similar, except for one outcome. In the Knee Injury and Osteoarthritis Outcome Score for function in sports and recreation, high-dose therapy was superior.
Family Medicine/General Practice February 8th 2023
Effect of Diet and Exercise on Knee Pain in Patients with Osteoarthritis and Overweight or Obesity
In a study of more than 800 rural-living men and women with knee osteoarthritis, an 18-month program of diet and exercise versus attention control yielded an average 14-pound greater weight loss in the test group – but not much difference in pain magnitude.
Family Medicine/General Practice January 5th 2023
Effectiveness of an Unsupervised Online Yoga Program on Pain and Function in People with Knee Osteoarthritis
In a study involving 212 adults with symptomatic knee osteoarthritis, an unsupervised online yoga program delivered via prerecorded videos over 12 weeks netted improved physical function vs. the control group. At 12 weeks, knee stiffness, quality of life, and arthritis self-efficacy improved more with yoga than the control intervention. Benefits were not maintained at 24 weeks. Adverse events were minor.
Family Medicine/General Practice September 26th 2022