Articles related to Family Medicine/General Practice

Emerging reports suggest some patients experience emotional blunting or reduced reward responsiveness after starting GLP-1 receptor agonists. Current evidence remains mixed, and available data have not established a causal relationship between GLP-1 therapy and diminished antidepressant response.

The FDA approved Freenome’s SimpleScreen CRC blood test for colorectal cancer screening in average-risk adults. Clinical study results showed the test detected roughly 80% of colorectal cancers, though current guidelines continue to favor colonoscopy and stool-based screening options.

A mathematical modeling study estimated that somatic DNA mutations alone could limit median human life span to roughly 146 to 194 years. The findings add to ongoing research suggesting that aging reflects multiple interacting biological processes rather than a single mechanism.

A gastroenterologist reflects on changing attitudes toward physician work culture, describing how younger physicians increasingly prioritize personal well-being alongside professional responsibilities. The commentary frames the shift as a response to longstanding expectations around endurance, productivity, and burnout.

Two long-term proton pump inhibitor users presented with severe macrocytic anemia, markedly elevated LDH, and low haptoglobin suggestive of hemolysis. Further evaluation identified combined vitamin B12 and folate deficiency, highlighting a diagnostic mimic of true hemolytic anemia.

A growing debate in airway management centers on whether clinicians should favor the term “complex airway” over “difficult airway.” An expert commentary argues that both concepts describe different dimensions of risk and should remain part of a shared airway-management vocabulary.