Articles related to Hepatology

The adenoviral vector–based gene therapy contains the gene for interferon alfa-2b. It is administered by catheter into the bladder once every three months. The virus penetrates the bladder endothelial cells and releases the gene, which is incorporated by the cells. As a result, the cells begin secreting high levels of the cancer-fighting interferon.

In an analysis of 19 studies across 12 countries involving more than 25,000 participants, individuals in highest 20% bracket for omega 3 levels had 13% less risk for developing CKD compared with participants in the lowest 20% bracket. Results were consistent and independent of subgroup variables of age, GFR, hypertension, CAD, and diabetes.

Updated recommendations include EGD with multiple duodenal biopsies, setting intestinal healing as the goal for gluten-free diet, and use of gluten-free oats in some populations. There wasn’t evidence to support routine use of probiotics or use of gluten detection devices.

On exam, this 19-year-old woman has malar rash characterized by pink-violet papules and plaques with no other physical finding. ANA is positive and urinalysis is remarkable for 3+ blood and protein. What test is the most appropriate next step?

A layered approach to care is described with lifestyle interventions being a key feature of the updated recommendations. The recommendations now include therapies proven to improve cardiovascular and kidney outcomes in patients with diabetes and CKD.

Sunlenca (lenacapavir), which comes in 300 mg tablets and a 463.5 mg/1.5 mL injection, provides doctors with a long-needed twice-yearly option for patients with complicated past treatment histories who would otherwise have few treatment options.