Articles related to Reproductive Endocrinology

A new Endocrine Society guideline favors watchful waiting over immediate evaluation for many girls with early breast development, narrows brain MRI and genetic testing to select cases, and sets age limits for stopping GnRH agonist therapy.

PCOS was associated with significantly elevated risk for breast, uterine, ovarian/fallopian tube, and cervical cancers in a matched cohort of more than 2.5 million women.

A JCEM clinical guidance article outlines a two-criterion diagnostic standard for adolescent PCOS, requiring both persistent hyperandrogenism and menstrual irregularity, and frames adolescence as the critical window for metabolic and psychosocial risk stratification.

A case of chemotherapy-induced menopause left unmanaged for six years prompted a physician’s pointed critique of survivorship care failures, highlighting the clinical and legal stakes of untreated premature ovarian insufficiency following gonadotoxic therapy.

The American Thyroid Association released updated evidence-based recommendations for thyroid disease in preconception, pregnancy, and postpartum, incorporating new trial data on LT4 treatment thresholds, TPOAb management, and ATD safety that diverge meaningfully from 2017 guidance.

Hematopoietic loss of the X chromosome in peripheral blood was associated with more than twofold the odds of failing to conceive naturally in a Japanese multicenter case-control study, with no corresponding association found in women undergoing ART.