Articles related to Reproductive Endocrinology

Semaglutide use before or during pregnancy was associated with greater gestational weight gain and several adverse outcomes in a retrospective cohort, although similar findings among former users complicate attribution to direct fetal exposure.

Intrauterine mepivacaine administered shortly before IUD placement reduced procedural pain and improved patient-reported experience in a randomized trial of women receiving smaller-diameter IUDs, although comparisons with other analgesic approaches remain limited.

Testosterone prescribing for women has risen sharply despite the absence of FDA-approved female-specific products. The increase is occurring alongside pharmacy dispensing barriers and renewed regulatory attention, while guideline-supported use remains largely limited to hypoactive sexual desire disorder in postmenopausal women.

A new Endocrine Society guideline favors watchful waiting over immediate evaluation for many girls with early breast development, narrows brain MRI and genetic testing to select cases, and sets age limits for stopping GnRH agonist therapy.

PCOS was associated with significantly elevated risk for breast, uterine, ovarian/fallopian tube, and cervical cancers in a matched cohort of more than 2.5 million women.

A JCEM clinical guidance article outlines a two-criterion diagnostic standard for adolescent PCOS, requiring both persistent hyperandrogenism and menstrual irregularity, and frames adolescence as the critical window for metabolic and psychosocial risk stratification.