Articles related to Neurology

This review summarizes the clinical presentation, workup, staging, and recent advancements in the treatment of PCNSL. Although treatment advances include the use of BTK inhibitors and immunomodulators, relapse is common and 5-year survival is 40% or lower. Thus, accurate early diagnosis and initiation of treatment is time sensitive for optimal neurologic recovery and disease control.

Test your clinical knowledge on JB, a right-handed, 35-year-old patient with a history of generalized anxiety disorder, who came into the clinic to be evaluated and managed for atypical movements that started in adolescence. JB frequently exhibits quick shoulder shrugs, abrupt head movements to the right, and throat clearing during the neurologic examination. Examination results for the cerebellum, motor, sensory, and reflexes are unremarkable.

The TRAILBLAZER-ALZ Randomized Clinical Trial According to the findings of post-hoc analysis for patients who received donanemab treatment, baseline amyloid levels were directly related to the extent of amyloid reduction and inversely related to the likelihood of obtaining total amyloid clearance. In patients with complete amyloid clearance and in brain areas discovered later in the pathologic sequence, the donanemab-induced slowing of tau was more severe. To support the aforementioned findings, data from additional trials would be crucial, particularly information on treatment response according to APOE ε4 status.

A total of 35 status migrainosus patients were enrolled; 30 of them were female, and the average age was 39. Before the drugs were given, everyone’s serum magnesium levels were normal. There were no ECG alterations found, and none of the patients experienced any severe side effects either during or right away following the infusion. In 15 patients, there was a positive effect; in 10, there was no effect; and in 10, there were no data.

The colorful fentanyl, known as “rainbow fentanyl,” has been identified in 18 different states and has been found in a variety of forms, including pills, powder, and blocks that resemble sidewalk chalk, according to a press release from the agency. No particular color has been found to have a higher potency through testing. According to the DEA, every shade, shape, and size should be viewed as being exceedingly harmful.

This report on learnings shows that it is crucial to educate primary healthcare professionals on how to spot people who may commit suicide in their later years (eg, using “The 5 Ds” — Deadly methods, Depression, Disease & Disability, Disconnectness, and Development) and how to adopt prevention measures.