Articles related to NEURODEGENERATIVE DISEASES

Women with Parkinson disease exhibited greater Alzheimer-related amyloid plaque burden than men in an autopsy-confirmed cohort, although cognitive performance and dementia rates were similar between sexes.

BCG vaccination increased immune responsiveness without inflammatory activation and shifted beta-amyloid patterns in a small mechanistic study of older adults.

Frontal release sign positivity was associated with a 78% higher hazard of developing dementia among cognitively intact adults aged 70 and older in a longitudinal cohort study at a single academic Alzheimer’s research center.

Survey responses from 5,797 Fox Insight participants suggest sleep disturbances, autonomic dysfunction, and emotional changes preceded Parkinson’s disease diagnosis by more than a decade in a substantial proportion of respondents.

The LRRK2 inhibitor BIIB122 failed to slow disease progression versus placebo in 648 early-stage idiopathic Parkinson’s patients in the Phase 2b LUMA trial, leading Biogen and Denali to discontinue joint development.

Researchers are increasingly studying peripheral biomarkers in high-risk populations to improve diagnosis and prediction, with standard therapies currently limited to temporary symptom relief.