Articles related to RISK STRATIFICATION

A National Early Warning Score (NEWS)-based discharge protocol showed no statistically significant reduction in 72-hour ICU readmissions in a single-center quality improvement initiative. Length of stay and rapid-response activations also did not significantly differ between groups.

Frailty in a 68-patient ATTR-CM cohort was independently associated with more advanced amyloidosis stage and greater functional impairment, while age and interventricular septal thickness were not independently associated with frailty.

In patients with early multiple sclerosis starting interferon beta-1a, serum neurofilament light chain levels predicted progression before MRI findings were considered, but did not provide independent long-term prognostic value after adjustment for baseline imaging.

In a retrospective memory-clinic cohort, greater MRI-derived brain age was associated with dementia progression among patients with subjective cognitive decline, although its incremental predictive value was limited and external validation remains necessary.

Among individuals with progressive multiple sclerosis, higher blood neurofilament light chain (NfL) levels were associated with lower daily ambulatory activity, while increases in NfL over time tended to track with subsequent declines in step counts measured by wearable devices.

Among newly diagnosed, treatment-naive patients with multiple sclerosis, gut microbiome profiles differed from healthy controls and were associated with MRI features linked to poorer prognosis, suggesting a potential future role for microbiome-based risk stratification.