Articles related to RISK STRATIFICATION

An updated review of multiple myeloma management highlights revised high-risk definitions, anti-CD38-based quadruplet induction regimens, evolving maintenance strategies, and increasing use of CAR-T and bispecific immunotherapies across the disease continuum.

Three-year increases or sustained elevations in NT-proBNP were associated with greater cardiovascular and mortality risks among older adults without prior cardiovascular disease. Participants whose elevations resolved had risks resembling those who remained free of heart stress.

A retrospective study of 606 pediatric patients found serum specific IgE testing for allergic rhinitis was frequently negative in children younger than 3 years and became more informative with age. Findings may aid diagnostic decision-making, though prospective validation is needed.

Natural language processing models analyzing speech from children ages 9 to 13 predicted future mental health conditions more accurately than expert-rated stress assessments. Findings suggest linguistic patterns may serve as an early risk signal, though validation in larger cohorts is still needed.

In a single-center cross-sectional study of 75 symptomatic patients, coronary artery calcium score and carotid intima-media thickness were associated with CT-derived CAD severity. The findings support risk-stratification interest but require prospective validation.

The 2026 ACC/AHA dyslipidemia guideline reintroduces LDL-C treatment targets, expands risk assessment, and recommends universal Lp(a) screening. New analyses suggest many US adults now exceed recommended cholesterol thresholds, although treatment decisions remain individualized.