Articles related to MULTIPLE SCLEROSIS (MS)

An experimental cell therapy that couples a patient’s red blood cells with myelin protein fragments was well tolerated in a 10-patient Phase 1b study and was associated with increases in regulatory T-cells and reductions in neurofilament light chain, a biomarker linked to nerve injury.

A state Supreme Court reinstated a malpractice lawsuit involving delayed multiple sclerosis diagnosis after determining that unresolved questions remained regarding whether failure to communicate abnormal MRI findings may have deprived a patient of earlier treatment and a potentially better clinical position.

A novel small molecule, CN045, promoted oligodendrocyte maturation and modest remyelination in preclinical models of multiple sclerosis. The findings support an emerging strategy aimed at repairing damaged myelin, though clinical applicability remains unproven.

A network meta-analysis found that long-term vitamin D supplementation added to standard multiple sclerosis therapy was associated with reduced relapse risk and improved disability outcomes.

Differences in cerebrospinal fluid proteins distinguished women with multiple sclerosis from age-matched controls in a small exploratory study, highlighting potential hormonal and immune-related biological mechanisms. Findings require validation in larger populations before clinical application.

A network meta-analysis of 15 randomized trials found that no pharmacologic treatment outperformed placebo for MS-related fatigue severity, though amantadine and fampridine showed statistically significant and potentially clinically meaningful improvements in fatigue-related daily functioning.