Articles related to Nephrology

In patients with end-stage kidney disease, extraosseous calcification presents a complex clinical challenge, involving an active process with significant implications for patient management and outcomes. Understanding its pathogenesis and treatment options is crucial for optimizing care.

In patients with chronic kidney disease, the elevated troponin challenge necessitates a nuanced approach, integrating serial measurements and clinical context to discern acute coronary syndrome from chronic elevations, thereby informing targeted management strategies.

SGLT-2 inhibitors have emerged as a cornerstone in managing HFrEF and CKD, demonstrating substantial reductions in cardiovascular and renal adverse outcomes. This class of medications is reshaping the therapeutic approach in patients with these comorbid conditions, providing a dual benefit that was once considered challenging to achieve.

In the KEYNOTE-564 trial, adjuvant pembrolizumab demonstrated a significant improvement in disease-free survival among patients with renal-cell carcinoma at high risk of recurrence after nephrectomy, offering a new direction in post-surgical treatment strategies.

In a recent study assessing chronic insomnia treatments in hemodialysis patients, no significant difference was observed between CBT-I, trazodone, and placebo in improving Insomnia Severity Index scores. This highlights a critical need for alternative therapeutic approaches in this unique patient population.

Recent studies reveal that adding ezetimibe to lower-intensity statin therapy is as effective as high-intensity statin therapy alone in preventing major cardiovascular events, offering a new approach to lipid management in patients intolerant to high-intensity statins.