Articles related to Nephrology

Hereditary TTP, an ultra-rare ADAMTS13 deficiency affecting roughly one in a million, is now managed with weekly recombinant ADAMTS13 infusions in a pediatric outpatient setting.

According to the Gould Registry, in 5,006 patients with ASCVD, only one in three patients had LDL cholesterol even less than 70mg/dl.

Studies on fluid restriction in patients with HF are scarce, and most of the available studies are at high risk of bias. Although power is lacking, there is no evidence indicating that fluid restriction affects mortality or HF hospitalizations, but there is a signal of harm in terms of thirst distress.

The researchers discovered that findings among older adults reinforced the guideline shift toward personalized, risk-based care.

“People who maintain low levels of LDL-C and triglycerides at earlier ages are much less likely to develop atherosclerotic disease decades later.” — Pamela B. Morris, MD, FACC, FAHA, guideline writing committee vice-chair

“CHIP, especially non-DNMT3A CHIP, was independently associated with incident HF. Future research should explore the gene-specific mechanisms by which CHIP variants promote HF in humans.” — Study Authors, JAMA Cardiology