Articles related to Pathology

Ipsen voluntarily withdrew tazemetostat in follicular lymphoma and epithelioid sarcoma after 18 of 318 SYMPHONY-1 participants developed hematologic second primary malignancies, including three deaths.

Adding niraparib to abiraterone prolonged radiographic progression-free survival in BRCA-mutant metastatic hormone-sensitive prostate cancer, with overall survival data still maturing.

Invasive mucinous adenocarcinoma carries elevated NRG1 fusion burden that standard DNA-based sequencing reliably misses, while an FDA-approved targeted therapy now exists for confirmed cases.

A widely shared r/medicine thread drew candid, self-identified physician commentary on which specialties absorb the most interprofessional scrutiny, with emergency medicine and primary care drawing the heaviest fire.

When glutamate binds to the cancer cells’ NMDA receptors, a channel opens and calcium flows into the cell. This influx triggers molecular signaling cascades that drive tumor growth and metastasis.

Most medications are eliminated by the kidneys and appear in urine, enabling objective detection through mass spectrometry that can spur clinical discussions about barriers to medication adherence, absorption issues, and potentially new treatment plans.