Articles related to PRECISION MEDICINE

Emerging evidence suggests microbiome composition may be associated with immunotherapy response, toxicity, and outcomes in kidney cancer. Experts caution that inconsistent methodologies and limited reproducibility continue to challenge microbiome biomarker development.

A case report describes successful kidney transplantation in a highly sensitized patient whose probability of finding a compatible donor had been considered effectively zero. Treatment with teclistamab substantially reduced anti-HLA antibodies, enabling transplantation after prolonged wait-list status.

Female mice recovering from a single ketamine exposure demonstrated microglia-driven neuroplasticity through FKBP51 activation, while male mice did not. The findings identify a sex-specific biologic pathway in a preclinical model, and human relevance remains unconfirmed.

A repeat PSMA PET/CT scan detected recurrent disease in more than half of prostate cancer patients whose initial scan was negative. Findings altered management in nearly half of patients, particularly those with oligometastatic recurrence.

Analysis of genetic testing data from nearly 180,000 individuals with autism suggests that Phelan-McDermid syndrome may affect approximately 1 in 7,300 people. The findings indicate the condition may be substantially more common than previously estimated and highlight ongoing diagnostic gaps.

A high-sensitivity KRAS-targeted blood test detects residual pancreatic cancer missed by standard assays, suggesting current monitoring approaches may underestimate recurrence risk despite treatment.