Articles related to PRECISION MEDICINE

Older adults with advanced or metastatic urothelial carcinoma treated with enfortumab vedotin experienced substantially higher rates of severe toxicity and treatment discontinuation than younger patients, while survival outcomes appeared similar across age groups.

Biobehavioral markers previously linked to antidepressant response identified patients with major depressive disorder who were more likely to respond to sertraline or bupropion, although biomarker-guided treatment assignment did not significantly improve outcomes in a prospective validation trial.

Early detection remains one of the strongest tools against prostate cancer, with localized disease associated with nearly 100% 5-year survival. An oncology nursing review highlights screening, risk stratification, precision medicine, and the expanding role of nurses in education, care coordination, and survivorship support.

Among newly diagnosed, treatment-naive patients with multiple sclerosis, gut microbiome profiles differed from healthy controls and were associated with MRI features linked to poorer prognosis, suggesting a potential future role for microbiome-based risk stratification.

Tumor genomes may evolve during treatment as resistant subclones emerge under therapeutic pressure, prompting increasing use of comprehensive genomic profiling and serial ctDNA testing to inform ongoing precision oncology decisions.

Genetic testing identifies causative variants in approximately 65% to 70% of suspected inherited retinal disease cases and may shorten diagnostic delays. Advances in sequencing technologies and expanding testing access continue to shape retinal disease evaluation and counseling.