Articles related to GENOMICS

Single-nucleus multi-omics sequencing across genetically diverse ASD mouse models revealed convergent molecular and cellular changes in early brain development, despite distinct underlying mutations.

A new analytical framework applied to 30,000+ parent-child trios found that uninherited parental genes shape children’s height, BMI, and academic performance to a degree approaching the influence of children’s own DNA.

A phase 3 randomized trial of 449 children with intracranial ependymoma found no significant event-free or overall survival benefit from adding maintenance chemotherapy after radiation, while molecular markers — particularly 1q gain and 6q loss — identified a high-risk posterior fossa subgroup with substantially worse outcomes.

A DNA methylation–based IgE score measured in infancy was associated with recurrent wheezing by age 3 across three pediatric cohorts.

Among the people who ate the least meat, the ones with the APOE 3/4 and 4/4 variants had over twice the risk of dementia than those who did not have these variants.

“CHIP, especially non-DNMT3A CHIP, was independently associated with incident HF. Future research should explore the gene-specific mechanisms by which CHIP variants promote HF in humans.” — Study Authors, JAMA Cardiology