American Society of HematologyActivity of mRNA COVID-19 Vaccines in Patients with Lymphoid Malignancies

Publication: Blood AdvancesDesign: Multicohort study, 46 total patients (23 patients with lymphoma/CLL and 23 healthy adults, all of whom received the mRNA vaccine)Conclusion: Patients with lymphoid malignancies, and most dramatically those with recent anti-CD20 monoclonal antibody treatment, have reduced humoral responses to mRNA COVID-19 vaccines as compared with healthy control. Related Article: Efficacy of the […]

American Society of HematologyClonal Hematopoiesis in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy

Source: Blood AdvancesKey Points: In a cohort of 154 patients with NHL or MM receiving CAR T-cells, clonal hematopoiesis of indeterminate potential (CHIP) was present in 48%. Although associated with worse prognosis in these patients receiving autologous transplantation, no such association was seen in these patients receiving CAR T. Instead, the authors saw increased rates […]

American Society of HematologyFDA Accepts sNDA for Zanubrutinib in Waldenström Macroglobulinemia

More good news for zanubrutinib, which received accelerated approval in November 2019 in the US for the treatment of mantle cell lymphoma (MCL) in adult patients who have undergone at least one prior therapy. The supplemental new drug application (sNDA) was submitted by the drug’s manufacturer, BeiGene, based on data from the global phase III […]