Articles related to LEUKEMIA
The Role of Allogeneic Transplant for Adult Ph+ ALL in CR1 with Complete Molecular Remission: A Retrospective Analysis
Acute lymphoblastic leukemia (ALL) with Philadelphia chromosome positivity (Ph+) has a poor prognosis historically, so allogeneic hematopoietic cell transplantation (allo-HCT) is advised after the first complete remission (CR1). The rapid achievement of a complete molecular remission (CMR), however, is associated with excellent outcomes without allo-HCT in the tyrosine kinase inhibitor (TKI) era, indicating transplant may not be necessary for these patients. To test this theory, the authors of this journal-based CME program looked into 5 transplant centers in the US to find adult Ph+ ALL patients who received induction therapy, such as TKIs, and received CMR within 90 days of diagnosis. They then compared the outcomes of people who received allo-HCT in the first remission versus those who did not.
Hematology November 28th 2022
CLL-IPI Applied in Binet A CLL: A Nationwide Cohort Study
This study provides evidence that older patients with Binet stage A CLL, including those in the oldest age groups, can receive the Chronic Lymphocytic Leukemia International Prognostic Index (CLL-IPI). Because of the high median age in our study, we were also able to identify a relationship between del(17p) and age, which raises the possibility that age-adjusted prognostic tools could enhance CLL prediction. In cardiology, risk stratifications and recommendations for antilipid treatment have long taken into account the interaction between age and other risk factors for fatal cardiovascular disease, but in CLL, age is typically only considered as an additive factor in prognostic models.
Hematology November 14th 2022
Phase 3 Trial of Gilteritinib plus Azacitidine vs. Azacitidine for Newly Diagnosed FLT3(mut+) AML Ineligible for Intensive Chemotherapy
The CRc rate was higher with GIL + AZA than with AZA in FLT3mut+ AML patients who were not suitable for intensive chemotherapy. In addition, OS did not differ significantly between GIL + AZA and AZA in FLT3mut+ AML patients who were not suitable for intensive chemotherapy.
Hematology November 7th 2022
The Clinical Importance of Prognostic Markers in CLL
A Q&A with John N. Allan, MD, Assistant Professor of Medicine in the Division of Hematology and Medical Oncology at Weill Cornell Medicine in New York, who discusses the changing role of prognostic markers, the usefulness of the markers, the biomarkers that should be part of standard testing, when patients should be tested, and much more.
Hematology October 19th 2022
Diagnosis and Management of AML in Adults: 2022 Recommendations from an International Expert Panel on Behalf of the ELN
Among doctors and researchers, the 2010 and 2017 versions of the European LeukemiaNet (ELN) recommendations for the diagnosis and treatment of acute myeloid leukemia (AML) in adults are broadly accepted. Researchers now have a better understanding of how AML develops from a molecular perspective, which has led to an update on the classification of the disease. Additionally, genomic diagnostics and the evaluation of measurable residual disease have advanced significantly, and new therapeutic agents like FLT3, IDH1, IDH2, and BCL2 inhibitors have been developed successfully. This update, which contains updated response criteria, therapy suggestions, and a revised ELN genetic risk classification, is a result of these developments.
Hematology September 26th 2022
Busulfan Plus Cyclophosphamide vs. Total Body Irradiation Plus Cyclophosphamide for Adults Acute B Lymphoblastic Leukemia: An Open-Label, Multicenter, Phase III Trial
Over a 4-year period, 500 patients were distributed equally between the two regimens. Two-year OS, relapse rates, and non-relapse mortality were similar between the two regiments, indicating that the busulfan regimen is non-inferior to the traditional TBI regimen.
Hematology September 19th 2022