Articles related to AUTOIMMUNE DISORDERS

An experimental cell therapy that couples a patient’s red blood cells with myelin protein fragments was well tolerated in a 10-patient Phase 1b study and was associated with increases in regulatory T-cells and reductions in neurofilament light chain, a biomarker linked to nerve injury.

Two phase 3 trials found upadacitinib increased scalp, eyebrow, and eyelash regrowth in adolescents and adults with severe alopecia areata. Longer-term safety, durability, and regulatory review remain important considerations.

The American Thyroid Association released updated evidence-based recommendations for thyroid disease in preconception, pregnancy, and postpartum, incorporating new trial data on LT4 treatment thresholds, TPOAb management, and ATD safety that diverge meaningfully from 2017 guidance.

A middle-aged woman with a four-year bipolar disorder diagnosis continued deteriorating despite psychiatric treatment until clinical reassessment pointed toward anti-NMDA receptor encephalitis, an autoimmune condition whose psychiatric prodrome frequently delays correct diagnosis.

The findings support, whenever possible, prioritizing higher-intensity activities in clinical and public health interventions aimed at preventing non-communicable diseases.

Early treatment phases may transiently promote immune activation, whereas sustained therapy, by reducing BMI and lowering systemic inflammation, may mitigate this effect.