Articles related to THYROID DISEASE

A recent study underscores the delicate balance required in thyroid hormone therapy for older adults, highlighting a clear association between thyrotoxicosis and heightened cognitive disorder risk.

In this target trial emulation involving nearly 44,000 patients with primary hyperparathyroidism (PHPT), similar declines in kidney function at 5 and 10 years were seen in patients managed with parathyroidectomy and in those managed nonoperatively. Thus, in this study, parathyroidectomy had no effect on long-term kidney function in older adults with PHPT.

The author concludes that “careful use of T3  and L-T4  can be critical mood-stabilizingoptions, especially for depressive illness that has not responded to first-line therapies,and can provide an alternative to other augmentation strategies such as atypicalantipsychotics, lithium, or esketamine/ketamine.”

Levothyroxine, which is the third most popular drug in the US and the main drug used to treat primary hypothyroidism, also possesses clinically significant interactions with food, beverages, and supplements that can change the safety and efficacy of thyroid-hormone replacement therapies. This review article from Pharmaceuticals reviews 925 hypothyroid patients that highlighted “disturbing” lifestyle and diet patterns.

Can you figure out the cause of this progressing discoloration on the bilateral anterior thighs of this 48-year-old patient? The patient denies pain, itching, or blistering, but her medical history is relevant for hypothyroidism. Any guesses?