Articles related to DEPRESSION

“The amygdala’s response to social threat appears to feed into depressive symptoms much more strongly in young males than in young females.” — John Krystal, MD, Biological Psychiatry

Note that many questions remain after this trial returned results that are not unequivocally positive. The prespecified primary outcome was negative, which limits claims of efficacy and argues against overinterpreting the study as confirmatory evidence for psilocybin in treatment-resistant depression.

“Semaglutide and, to a lesser extent, liraglutide were associated with significantly lower risk of worsening mental illness.” – Lead Study Researcher Heidi Taipale, PhD, University of Eastern Finland and Niuvanniemi Hospital

“Additional studies with larger samples and more detailed measures of ACE severity, frequency, and duration are essential.” – Ying Xiong, PhD, Karolinska Institutet, JAMA Network Open, 2026

“These findings support AMPA receptors as a clinically relevant treatment target in MDD.” – Samantha Yohn, PhD, Neurocrine Biosciences, Psych Congress NP Institute, 2026

The study authors concluded, “These findings further our understanding of shared and distinct neural mechanisms underlying mood disorders and assist in differential diagnosis, thereby guiding more accurate treatment strategies.”