Articles related to DEPRESSION

Biobehavioral markers previously linked to antidepressant response identified patients with major depressive disorder who were more likely to respond to sertraline or bupropion, although biomarker-guided treatment assignment did not significantly improve outcomes in a prospective validation trial.

Growing evidence suggests that exposure to natural environments may improve mood, attention, and selected cognitive functions, although the current literature remains insufficient to establish nature-based interventions as validated treatments for psychiatric disorders.

A systematic review of 12 studies found that vortioxetine consistently improved depressive symptoms in adults aged 65 years and older with major depressive disorder, but evidence for cognitive benefits remained mixed and largely confined to selected cognitive domains.

A single-day inhaled mebufotenin regimen produced rapid, sustained symptom reductions through day 8 in 10 patients with postpartum depression, but the uncontrolled trial provides an early clinical signal rather than comparative efficacy evidence.

Magnetoencephalography-based analysis of 263 patients with major depressive disorder identified five distinct brain connectivity profiles, each associated with differing symptom patterns, supporting the view that depression may encompass biologically heterogeneous subgroups rather than a single neurobiological condition.

In a nationwide cohort of more than 2,700 U.S. children, parenting profiles characterized by higher positive engagement and stronger supervision were associated with fewer emotional and behavioral problems, while poorer supervision and inconsistent discipline were associated with greater symptom burden.