Articles related to EARLY DETECTION

A two-year analysis of 12,670 screened men found that the Stockholm3 risk model detected more clinically significant prostate cancers than PSA testing alone, primarily through fewer false-negative results. The findings suggest improved screening discrimination, although follow-up remains limited to two years.

A multivariable screening test detects 90% of clinically significant prostate cancers vs 74% with PSA alone, suggesting PSA thresholds may miss aggressive disease despite similar false-positive rates.

Survey responses from 5,797 Fox Insight participants suggest sleep disturbances, autonomic dysfunction, and emotional changes preceded Parkinson’s disease diagnosis by more than a decade in a substantial proportion of respondents.

The American Cancer Society updated its colorectal cancer screening guidelines to include two new multitarget stool tests and a blood-based option, while maintaining colonoscopy as the gold standard and the age-45 screening initiation recommendation for average-risk adults.

After 23 years, men offered once-only sigmoidoscopy had 1.7 fewer colorectal cancers and 0.8 fewer CRC deaths per 100. In women, the mortality benefit didn’t reach significance.

Multiple Alzheimer disease biomarkers showed accelerated age-related changes near age 70 in a Mayo Clinic Study of Aging cohort, identifying potential screening and monitoring windows.