Articles related to EVIDENCE REVIEW

A systematic review and meta-analysis linked plasma exchange with high recovery rates in MOGAD attacks, especially optic neuritis. Included studies were observational and could not isolate PLEX effects.

In a 3-year randomized clinical trial, dialectical behavior therapy and schema therapy produced substantial improvements in borderline personality disorder severity. No statistically significant differences were observed between treatments on primary or secondary outcomes.

Fluvoxamine reduced fatigue and improved quality-of-life measures in adults with long COVID in a randomized placebo-controlled trial. The findings provide evidence for a potential therapy, although further research is needed to define optimal patient selection and treatment strategies.

A rapid review found that ADHD stimulant misuse declined in several recent US surveys, particularly among younger adults, although millions continued to report misuse. Evidence linked frequent misuse with polysubstance use, while long-term health consequences remain poorly characterized.

A meta-analysis of 14 observational studies found that very high chili pepper consumption was associated with increased gastrointestinal cancer risk, particularly esophageal cancer. The findings were observational and did not establish a causal relationship between chili pepper intake and cancer development.

A network meta-analysis found that long-term vitamin D supplementation added to standard multiple sclerosis therapy was associated with reduced relapse risk and improved disability outcomes.