Articles related to EVIDENCE REVIEW

A systematic review of 30 longitudinal MRI studies found that CPAP therapy in obstructive sleep apnea (OSA) may be associated with structural, functional, vascular, and metabolic brain changes. However, the evidence remains heterogeneous, largely exploratory, and insufficient to support routine MRI monitoring of treatment response.

A systematic review and meta-analysis of studies involving more than 230,000 adolescents found that greater social jet lag was associated with higher anxiety levels. The findings identified a consistent but small association and did not establish causality.

A systematic review and meta-analysis found that inclisiran significantly reduced LDL cholesterol compared with placebo across diverse hyperlipidemia populations. Long-term cardiovascular outcome data remain limited despite consistent lipid-lowering efficacy and favorable safety findings.

A meta-analysis of seven studies found cannabinoid-based therapies were associated with lower agitation and neuropsychiatric symptom scores in patients with moderate to severe Alzheimer disease. Cognitive benefits were not consistently observed, and somnolence occurred more frequently with treatment.

A systematic review and meta-analysis linked plasma exchange with high recovery rates in MOGAD attacks, especially optic neuritis. Included studies were observational and could not isolate PLEX effects.

In a 3-year randomized clinical trial, dialectical behavior therapy and schema therapy produced substantial improvements in borderline personality disorder severity. No statistically significant differences were observed between treatments on primary or secondary outcomes.