Articles related to CANCER BIOLOGY

Analysis of 189 colorectal tumors linked younger age to differences in stromal composition and gene activity. Additional datasets supported the stromal finding, but the study did not establish that these patterns cause aggressive disease.

Proteomic analysis of normal ovaries from 28 postmenopausal women identified age-associated differences in inflammation and tissue remodeling. The findings describe molecular activity, not restored fertility, and do not establish cancer risk or benefits from ovarian removal.

Analysis of postmenopausal ovarian tissue from 28 women found that ovaries continue to undergo molecular remodeling decades after menopause, with age-related increases in inflammatory and tissue-remodeling pathways that overlap with biologic processes observed in ovarian cancer.

Gliomas and ependymomas appear to reuse developmental hierarchies, progenitor states, and neural-circuit signals that shape tumor heterogeneity and treatment response, although many proposed therapeutic vulnerabilities remain supported primarily by preclinical evidence.

Researchers identified a transfer RNA, tRNA¹Arg(UCU), that appears to regulate androgen receptor dependence in prostate cancer. Preclinical studies suggest manipulating this pathway may influence treatment sensitivity and the development of drug-resistant disease states.

Researchers identified a previously unrecognized B7-H3-driven pathway that promotes immune suppression in castration-resistant prostate cancer. Preclinical findings suggest dual targeting of B7-H3 and MEK signaling altered the tumor microenvironment and improved antitumor activity in experimental models.