Articles related to BIOMARKERS

Artificial intelligence tools are increasingly being integrated into prostate cancer imaging, pathology, prognostication, and treatment planning. Although several platforms have demonstrated promising accuracy and workflow benefits, broad clinical adoption will require prospective validation, regulatory oversight, and careful implementation.

Researchers identified a metabolic pathway in which amino acid breakdown generates propionyl-CoA, sustaining cholesterol production and androgen signaling in prostate cancer models. The findings suggest a potential mechanism of hormone therapy resistance, though clinical relevance remains unproven.

A patient with advanced, treatment-resistant lung cancer experienced complete tumor disappearance after sodium selenite treatment and remained tumor-free for 10 years. The single case cannot establish efficacy, safety, or causality.

A multicenter cross-sectional study associated symptomatic uncomplicated diverticular disease with reduced microbial diversity and distinct taxonomic and predicted functional patterns. The findings remain hypothesis-generating and require validation in larger, longitudinal cohorts.

Maternal anti-HPA-1a antibodies inhibited β3 integrin activation in laboratory models, with stronger functional inhibition in severe FNAIT cases. The findings suggest a mechanism beyond platelet clearance, but clinical validation remains necessary.

A case report identified high-titer anti-RhD IgG antibodies in maternal breast milk as a potential source of ongoing hemolysis in an infant with persistent HDFN after exchange transfusion. The finding highlights a possible mechanism for delayed disease persistence but requires further validation.