Articles related to BIOMARKERS

Allergy testing in asthma is most useful when results could change management, with clinical history guiding targeted sensitization testing and total IgE serving a limited role outside anti-IgE biologic assessment.

A menopause-associated blood protein pattern was linked to poorer cognition and Alzheimer’s disease in older women across observational cohorts. Replication supports research interest, but the findings do not establish causality, individual prediction, or hormone-therapy prevention benefits.

Proteomic analysis of normal ovaries from 28 postmenopausal women identified age-associated differences in inflammation and tissue remodeling. The findings describe molecular activity, not restored fertility, and do not establish cancer risk or benefits from ovarian removal.

Frailty in a 68-patient ATTR-CM cohort was independently associated with more advanced amyloidosis stage and greater functional impairment, while age and interventricular septal thickness were not independently associated with frailty.

In patients with early multiple sclerosis starting interferon beta-1a, serum neurofilament light chain levels predicted progression before MRI findings were considered, but did not provide independent long-term prognostic value after adjustment for baseline imaging.

The revised McDonald criteria recognize the cerebrospinal fluid κFLC index as an alternative to oligoclonal bands for demonstrating intrathecal immunoglobulin synthesis, expanding laboratory options while preserving the need for integrated MS diagnosis.