Articles related to BIOMARKERS

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

PrimeC lowered neuron-derived TDP-43 levels in a Phase 2b ALS trial, with earlier analyses reporting functional and survival signals requiring confirmation in a planned pivotal study.

Differences in cerebrospinal fluid proteins distinguished women with multiple sclerosis from age-matched controls in a small exploratory study, highlighting potential hormonal and immune-related biological mechanisms. Findings require validation in larger populations before clinical application.

A multivariable screening test detects 90% of clinically significant prostate cancers vs 74% with PSA alone, suggesting PSA thresholds may miss aggressive disease despite similar false-positive rates.

A high-sensitivity KRAS-targeted blood test detects residual pancreatic cancer missed by standard assays, suggesting current monitoring approaches may underestimate recurrence risk despite treatment.

BCG vaccination increased immune responsiveness without inflammatory activation and shifted beta-amyloid patterns in a small mechanistic study of older adults.