Articles related to BIOMARKERS

Retinal imaging findings were associated with future atrial fibrillation diagnosis in two large UK datasets, with thinning of specific retinal nerve layers observed years before clinical detection. The study identified an early risk signal but did not establish causality or diagnostic utility.

Frontal tau accumulation was associated with disrupted deep-sleep slow waves and poorer episodic memory performance in older adults, offering a potential physiological link between Alzheimer’s-related pathology and age-related memory decline.

Muscle ultrasound measurements obtained before and after exercise distinguished patients with generalized myasthenia gravis from healthy controls in a small case-control study, suggesting a potential imaging approach for assessing fatigability.

Baseline activity in the left dorsolateral prefrontal cortex and right precuneus during working memory and emotion-regulation tasks was associated with depression severity one year later in young adults at elevated risk for affective disorders, but not with future mania symptoms.

Tumor genomes may evolve during treatment as resistant subclones emerge under therapeutic pressure, prompting increasing use of comprehensive genomic profiling and serial ctDNA testing to inform ongoing precision oncology decisions.

Prostate cancer screening continues to rely on individualized risk assessment, PSA monitoring, and shared decision-making, while advances in MRI imaging and biomarker testing may help refine biopsy decisions and reduce unnecessary invasive procedures.