Articles related to BIOMARKERS

Analysis of postmenopausal ovarian tissue from 28 women found that ovaries continue to undergo molecular remodeling decades after menopause, with age-related increases in inflammatory and tissue-remodeling pathways that overlap with biologic processes observed in ovarian cancer.

Biobehavioral markers previously linked to antidepressant response identified patients with major depressive disorder who were more likely to respond to sertraline or bupropion, although biomarker-guided treatment assignment did not significantly improve outcomes in a prospective validation trial.

Researchers identified regulatory variants affecting the X-linked gene MECP2 that may contribute to autism risk in males, offering a potential genetic explanation for part of the long-observed male predominance in autism spectrum disorder. Mutations associated with approximately 30% reductions in MECP2 expression produced autism-related phenotypes without causing classic Rett syndrome.

Across three cohorts, molecular patterns in human milk were associated with maternal nutritional status, mammary biological signatures, and infant growth. Seven candidate biomarkers emerged, but their clinical utility and the proposed vitamin B5 mechanism remain unproven.

Among individuals with progressive multiple sclerosis, higher blood neurofilament light chain (NfL) levels were associated with lower daily ambulatory activity, while increases in NfL over time tended to track with subsequent declines in step counts measured by wearable devices.

Researchers identified a transfer RNA, tRNA¹Arg(UCU), that appears to regulate androgen receptor dependence in prostate cancer. Preclinical studies suggest manipulating this pathway may influence treatment sensitivity and the development of drug-resistant disease states.