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TFOS DEWS III proposes a driver-based approach to dry eye disease, emphasizing standardized diagnosis, disease subtyping, and layered treatment strategies matched to underlying mechanisms rather than rigid severity-based escalation.

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Adjunctive low-dose naltrexone did not separate from placebo on depressive symptom reduction in a 38-patient randomized trial of adults with moderate major depressive disorder on existing antidepressants.