Articles related to CARDIOVASCULAR DISEASE (CVD)

Pregnancy is well tolerated for many women with congenital heart disease, but outcomes vary substantially by underlying lesion and clinical characteristics. Current guidance emphasizes multidisciplinary counseling, structured risk assessment, and individualized management before conception.

Among more than 117,000 women followed in two Nurses’ Health Study cohorts, greater resistance-training participation was associated with lower rates of major cardiovascular disease. Risk reductions were most pronounced when strength training was paired with aerobic exercise.

Premature menopause was linked to a 40% higher long-term risk of coronary heart disease in a pooled analysis of more than 10,000 women followed across six cohort studies.

The FDA approved olezarsen (Tryngolza), an apoC-III antisense inhibitor, as an adjunct to diet for reducing triglycerides and acute pancreatitis risk in adults with severe hypertriglyceridemia, based on phase 3 data showing an 85% reduction in pancreatitis events compared with placebo.

A 4-week randomized trial in 20 obese men with hypercholesterolemia found that intermittent hypoxic training combined with caloric restriction produced greater reductions in LDL-C, total cholesterol, and triglycerides compared with normoxic training under identical dietary conditions.

A Bayesian network meta-analysis of 31 randomized trials found aerobic, combined, and high-intensity interval training each associated with reductions in 24-hour ambulatory systolic blood pressure compared with control conditions, with no modality demonstrating clear superiority and all comparisons rated very low to low confidence.