Articles related to CARDIOVASCULAR DISEASE (CVD)

A consumer overview describes metformin’s potential roles in weight management, ovarian syndrome symptoms, and cardiovascular outcomes, but the reported findings involve different populations and do not establish equivalent benefits across these uses.

In a prospective cohort of more than 112,000 French adults, higher intake of several commonly used food preservatives was associated with increased risks of hypertension and cardiovascular disease, though the observational design cannot determine whether the additives themselves caused the observed outcomes.

In a secondary analysis of 371,038 U.S. adults, individuals reporting several cardiovascular disease (CVD) risk factors or established CVD reported less frequent whole-fruit consumption. The cross-sectional survey identified associations only and did not establish whether dietary behaviors preceded disease.

In a large multinational target-trial emulation, adults with serious mental illness who initiated GLP-1 receptor agonists experienced lower mortality and cardiovascular event rates than matched patients initiating SGLT2 inhibitors, though residual confounding remains a key limitation.

Retinal imaging findings were associated with future atrial fibrillation diagnosis in two large UK datasets, with thinning of specific retinal nerve layers observed years before clinical detection. The study identified an early risk signal but did not establish causality or diagnostic utility.

Analysis of NHANES data suggests that adoption of the 2026 ACC/AHA dyslipidemia guidelines could make approximately 25 million additional US adults eligible to consider statin therapy, primarily through incorporation of PREVENT risk equations and expanded emphasis on long-term cardiovascular risk.