Articles related to STATINS

The recent LODESTAR clinical trial has revealed that although the two statins are equally effective in preventing heart attacks, strokes, and death, one has been associated with a higher risk of developing type 2 diabetes and requiring cataract surgery.

A recent study involving 4,400 participants revealed that two major statins—rosuvastatin and atorvastatin—are equally effective at reducing heart attacks, strokes, and all-cause deaths. However, it was found that the rosuvastatin group was more likely (7.2%) to develop type 2 diabetes than the atorvastatin group (5.3%).

This study provides valuable insights into the comparative benefits and risks of rosuvastatin and atorvastatin in adults with coronary artery disease. Notably, while both drugs showed comparable efficacy, rosuvastatin was associated with a higher risk of new onset diabetes mellitus and cataract surgery.

A recent Danish cohort study reveals that older adults (≥75 years) may experience a more pronounced LDL-C reduction with low- to moderate-intensity statins than their younger counterparts. This finding emphasizes the need to consider age when prescribing statin therapy.

Bempedoic acid is currently approved for two patient subgroups. This 3-year, double-blind, randomized, placebo-controlled trial examined cholesterol-lowering and CV protective effects in a broader population of approximately 14,000 patients with elevated cholesterol who were unable or unwilling to take statins. The drug was 21% more effective than placebo at reducing LDL in this trial. There was a small but significant reduction in primary events of CV-related death, MI, stroke, or coronary revascularization.

This summary of a January 2023 JACC article highlights the study finding that rosuvastatin was “vastly superior to… any of the six supplements studied in the trial.” The study compared rosuvastatin to cinnamon, garlic, turmeric, red yeast rice, fish oil, and plant sterols. Rosuvastatin yielded a reduction in cholesterol of nearly 38 percent in just 28 days. The supplements had little to no effect but were significantly more costly than the statin.