Articles related to ALZHEIMER'S/DEMENTIA

A plasma p-tau217/Aβ42 ratio accurately identified amyloid-PET positivity in older veterans without traumatic brain injury, but diagnostic performance declined substantially among those with a history of TBI, particularly following more severe injuries.

Women with Parkinson disease exhibited greater Alzheimer-related amyloid plaque burden than men in an autopsy-confirmed cohort, although cognitive performance and dementia rates were similar between sexes.

Older adults’ real-time ratings of their mental sharpness closely tracked objective cognitive performance during everyday activities in a smartwatch-based study. The observational findings suggest potential utility for monitoring cognitive change but did not establish causality.

BCG vaccination increased immune responsiveness without inflammatory activation and shifted beta-amyloid patterns in a small mechanistic study of older adults.

Frontal release sign positivity was associated with a 78% higher hazard of developing dementia among cognitively intact adults aged 70 and older in a longitudinal cohort study at a single academic Alzheimer’s research center.

Glucosamine use was associated with a 25% increase in mortality risk in patients with Alzheimer’s disease-related dementia in a retrospective analysis of more than 50,000 patients, with no corresponding signal observed in those with mild cognitive impairment.