Articles related to ALZHEIMER'S/DEMENTIA

Frontal release sign positivity was associated with a 78% higher hazard of developing dementia among cognitively intact adults aged 70 and older in a longitudinal cohort study at a single academic Alzheimer’s research center.

Glucosamine use was associated with a 25% increase in mortality risk in patients with Alzheimer’s disease-related dementia in a retrospective analysis of more than 50,000 patients, with no corresponding signal observed in those with mild cognitive impairment.

A 509,926-patient Medicare cohort found that recombinant herpes zoster vaccination was associated with a 5.8 percentage point reduction in 4-year dementia risk among older adults following skilled-nursing facility admission, adding to a growing body of observational evidence linking RZV to cognitive protection.

Accelerometer-derived sleep-wake cycle metrics independently predicted incident dementia in 53,448 UK Biobank participants, with predictive improvement comparable to APOE genotype contribution when added to age-only models.

Brain-predicted age difference and socioeconomic status moderated the relationship between AD pathology markers and cognitive performance in a cross-sectional cohort of 621 cognitively unimpaired older adults.

A clinician review outlined how diagnostic confidence, staging, genetic risk, and imaging features inform patient selection for amyloid-targeting Alzheimer’s therapies.